Interleukin-10
The IL10 gene encodes a cytokine, interleukin 10, which is involved in various processes of immune regulation. Mutations cause IL10 deficiency that presents in various disturbances of immune regulation and infection defense.
Genetests:
Related Diseases:
References:
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Mazmanian SK et. al. (2008) A microbial symbiosis factor prevents intestinal inflammatory disease.
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Lard LR et. al. (2003) Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis.
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Singh UP et al. (2003) Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10-/- mice.
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Opdal SH et. al. (2003) IL-10 gene polymorphisms are associated with infectious cause of sudden infant death.
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Cooke KR et. al. (2003) A protective gene for graft-versus-host disease.
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6. |
Lin MT et. al. (2003) Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation.
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7. |
Moraes MO et. al. (2004) Interleukin-10 promoter single-nucleotide polymorphisms as markers for disease susceptibility and disease severity in leprosy.
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8. |
Lio D et. al. (2004) Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease.
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9. |
Ma CS et al. (2005) Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells.
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Fowler EV et al. (2005) TNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease.
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Malhotra D et. al. (2005) IL-10 promoter single nucleotide polymorphisms are significantly associated with resistance to leprosy.
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12. |
Froicu M et. al. (2006) Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice.
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13. |
Brooks DG et. al. (2006) Interleukin-10 determines viral clearance or persistence in vivo.
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14. |
Stein CM et al. (2007) Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes.
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15. |
Cassoux N et. al. (2007) IL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma.
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16. |
Natividad A et. al. (2008) Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation.
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17. |
Kim JM et. al. (1992) Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.
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Ouma C et. al. (2008) Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production.
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Dardalhon V et. al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.
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20. |
Németh K et. al. (2009) Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production.
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21. |
Sun J et. al. (2009) Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10.
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22. |
Said EA et. al. (2010) Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection.
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23. |
Villalta SA et. al. (2011) Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype.
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Kane M et. al. (2011) Successful transmission of a retrovirus depends on the commensal microbiota.
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25. |
Devkota S et. al. (2012) Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.
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Teles RM et al. (2013) Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.
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27. |
Olszak T et. al. (2014) Protective mucosal immunity mediated by epithelial CD1d and IL-10.
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28. |
Zigmond E et. al. (2014) Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis.
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29. |
Kabat AM et. al. (2017) Inflammation by way of macrophage metabolism.
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30. |
Ip WKE et. al. (2017) Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages.
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31. |
Tanaka S et. al. (2018) Trim33 mediates the proinflammatory function of Th17 cells.
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32. |
Esposito K et. al. (2003) Association of low interleukin-10 levels with the metabolic syndrome in obese women.
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33. |
Kemper C et al. (2003) Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype.
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Vieira P et. al. (1991) Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.
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35. |
Cox DR et. al. (1990) Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes.
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Chan CC et. al. (1995) Interleukin-10 in the vitreous of patients with primary intraocular lymphoma.
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Kühn R et al. (1993) Interleukin-10-deficient mice develop chronic enterocolitis.
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Crawley JB et. al. (1996) Interleukin-10 stimulation of phosphatidylinositol 3-kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine.
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39. |
Turner DM et. al. (1997) An investigation of polymorphism in the interleukin-10 gene promoter.
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40. |
Westendorp RG et. al. (1997) Genetic influence on cytokine production and fatal meningococcal disease.
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41. |
Eskdale J et. al. (1997) Mapping of the human IL10 gene and further characterization of the 5' flanking sequence.
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42. |
Rosenwasser LJ et. al. (1997) Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10).
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43. |
Gesser B et. al. (1997) Identification of functional domains on human interleukin 10.
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44. |
Meng X et. al. (1998) Keratinocyte gene therapy for systemic diseases. Circulating interleukin 10 released from gene-transferred keratinocytes inhibits contact hypersensitivity at distant areas of the skin.
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45. |
Eskdale J et. al. (1998) Interleukin 10 secretion in relation to human IL-10 locus haplotypes.
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Franchimont D et al. (1999) Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor.
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47. |
None (1999) IL-10: An "immunologic scalpel" for atherosclerosis?
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48. |
Pinderski Oslund LJ et. al. (1999) Interleukin-10 blocks atherosclerotic events in vitro and in vivo.
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49. |
Grove J et. al. (2000) Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease.
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Kitagawa N et. al. (2000) Epstein-Barr virus-encoded poly(A)(-) RNA supports Burkitt's lymphoma growth through interleukin-10 induction.
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51. |
Shin HD et. al. (2000) Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10.
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Summers AM et. al. (2000) Association of IL-10 genotype with sudden infant death syndrome.
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53. |
Gibson AW et. al. (2001) Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus.
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54. |
Asadullah K et al. (2001) Interleukin-10 promoter polymorphism in psoriasis.
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55. |
Farmer MA et al. (2001) A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice.
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Goudy K et. al. (2001) Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.
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57. |
Lee TS et. al. (2002) Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice.
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Lee CG et. al. (2002) Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways.
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Akbari O et. al. (2002) Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity.
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60. |
Alamartine E et. al. (2003) Interleukin-10 promoter polymorphisms and susceptibility to skin squamous cell carcinoma after renal transplantation.
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61. |
Shin HD et. al. (2003) Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma.
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Update: Aug. 14, 2020