Prokineticin-2
The PROK2 gene encodes a neuropeptide which is predominantly expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. Mutations autosomal dominant Kallmann syndrome 4.
Genetests:
Related Diseases:
References:
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Hanchate NK et al. (2012) SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.
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Dodé C et al. (2006) Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2.
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Pitteloud N et al. (2007) Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.
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Leroy C et al. (2008) Biallelic mutations in the prokineticin-2 gene in two sporadic cases of Kallmann syndrome.
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Cole LW et al. (2008) Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum.
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Jilek A et al. (2000) Murine Bv8 gene maps near a synteny breakpoint of mouse chromosome 6 and human 3p21.
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Li M et al. (2001) Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle.
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Cheng MY et al. (2002) Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus.
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Ng KL et al. (2005) Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling.
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Shojaei F et al. (2007) Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
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Giannini E et al. (2009) The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain.
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Update: Aug. 14, 2020