Hepatocyte growth factor receptor
The MET gene encode a tyrosin kinase type receptor which binds hepatocyte growth factor and plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations are associated with various tumors papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers.
Genetests:
Related Diseases:
References:
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Beals RK et al. (1976) Familial congenital bowing of the tibia with pseudarthrosis and pectus excavatum: report of a kindred.
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Finisguerra V et al. (2015) MET is required for the recruitment of anti-tumoural neutrophils.
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Rodgers JT et al. (2014) mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).
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Kaushansky A et al. (2011) The crucial role of hepatocyte growth factor receptor during liver-stage infection is not conserved among Plasmodium species.
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Zou C et al. (2007) Lack of Fas antagonism by Met in human fatty liver disease.
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Engelman JA et al. (2007) MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
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Campbell DB et al. (2006) A genetic variant that disrupts MET transcription is associated with autism.
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Veiga E et al. (2005) Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells.
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Carrolo M et al. (2003) Hepatocyte growth factor and its receptor are required for malaria infection.
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Giordano S et al. (2002) The semaphorin 4D receptor controls invasive growth by coupling with Met.
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Maina F et al. (2001) Coupling Met to specific pathways results in distinct developmental outcomes.
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Powell EM et al. (2001) Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating from the ventral to dorsal telencephalon.
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Shen Y et al. (2000) InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase.
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Park WS et al. (1999) Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas.
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Jeffers M et al. (1998) The mutationally activated Met receptor mediates motility and metastasis.
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Schmidt L et al. (1998) Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene.
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Jeffers M et al. (1997) Activating mutations for the met tyrosine kinase receptor in human cancer.
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Mujtaba G et al. (2015) A mutation of MET, encoding hepatocyte growth factor receptor, is associated with human DFNB97 hearing loss.
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Sunkara UK et al. (1997) Bilateral osteofibrous dysplasia: a report of two cases and review of the literature.
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Karol LA et al. (2005) Familial osteofibrous dysplasia. A case series.
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Gray MJ et al. (2015) Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia.
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Schmidt L et al. (1997) Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas.
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Zhuang Z et al. (1998) Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas.
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Boccaccio C et al. (2005) The MET oncogene drives a genetic programme linking cancer to haemostasis.
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None (1992) The met oncogene: from detection by transfection to transmembrane receptor for hepatocyte growth factor.
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Bottaro DP et al. (1991) Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.
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Park M et al. (1987) Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.
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Dean M et al. (1987) Chromosomal localization of the met proto-oncogene in the mouse and cat genome.
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Dean M et al. () The human met oncogene is related to the tyrosine kinase oncogenes.
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Cooper CS et al. () Molecular cloning of a new transforming gene from a chemically transformed human cell line.
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Maina F et al. (1996) Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development.
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Giordano S et al. (1997) A point mutation in the MET oncogene abrogates metastasis without affecting transformation.
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NCBI article
NCBI 4233
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OMIM.ORG article
Omim 164860
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Orphanet article
Orphanet ID 123201
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Wikipedia article
Wikipedia EN (C-Met)
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Update: Aug. 14, 2020