Mitochondrial uncoupling protein 3
The UCP3 gene encodes a mitochondrial anion transporter which is involved in the regulation of energy consumption and heat production. Mutations cause type 2 diabetes with severe obesity in an autosomal dominant fashion.
Genetests:
Related Diseases:
References:
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Fleury C et al. (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia.
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Choi CS et al. (2007) Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance.
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Russell AP et al. (2003) Decreased fatty acid beta-oxidation in riboflavin-responsive, multiple acylcoenzyme A dehydrogenase-deficient patients is associated with an increase in uncoupling protein-3.
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4. |
Mills EM et al. (2003) Pharmacology: uncoupling the agony from ecstasy.
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5. |
Hesselink MK et al. (2003) Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo.
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6. |
Dalgaard LT et al. (2001) A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population.
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7. |
Clapham JC et al. (2000) Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean.
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8. |
Vidal-Puig AJ et al. (2000) Energy metabolism in uncoupling protein 3 gene knockout mice.
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9. |
Gong DW et al. (2000) Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3.
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10. |
Brown AM et al. (1999) Endogenous mutations in human uncoupling protein 3 alter its functional properties.
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11. |
Hinz W et al. (1999) Recombinant human uncoupling protein-3 increases thermogenesis in yeast cells.
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12. |
Pecqueur C et al. (1999) Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene.
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13. |
Argyropoulos G et al. (1998) Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.
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14. |
Walder K et al. (1998) Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.
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15. |
Liu Q et al. (1998) Uncoupling protein-3: a muscle-specific gene upregulated by leptin in ob/ob mice.
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16. |
Boss O et al. (1998) Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13.
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17. |
Millet L et al. (1997) Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.
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18. |
Solanes G et al. (1997) The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts.
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19. |
Bouchard C et al. (1997) Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans.
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20. |
Vidal-Puig A et al. (1997) UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.
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21. |
Boss O et al. (1997) Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.
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22. |
Echtay KS et al. (2002) Superoxide activates mitochondrial uncoupling proteins.
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23. |
NCBI article
NCBI 7352
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24. |
OMIM.ORG article
Omim 602044
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25. |
Wikipedia article
Wikipedia EN (UCP3)
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Update: Aug. 14, 2020