Beta-2 adrenergic receptor
The ADRB2 encodes the beta-2-adrenergic receptor. Mutations can cause obesity which follows a dominant model. Also synergistic effects with mutations in other genes have to be taken into account. Also mutations have an effect on responsiveness to beta-2 agonists and the susceptibility to nocturnal asthma.
Genetests:
Related Diseases:
References:
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Tsai HJ et al. (2006) Beta 2-adrenergic receptor polymorphisms: pharmacogenetic response to bronchodilator among African American asthmatics.
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2. |
Meirhaeghe A et al. (2001) The effect of the Gly16Arg polymorphism of the beta(2)-adrenergic receptor gene on plasma free fatty acid levels is modulated by physical activity.
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3. |
Corbalán MS et al. (2002) The 27Glu polymorphism of the beta2-adrenergic receptor gene interacts with physical activity influencing obesity risk among female subjects.
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4. |
Bachman ES et al. (2002) betaAR signaling required for diet-induced thermogenesis and obesity resistance.
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5. |
Evans WE et al. (2003) Pharmacogenomics--drug disposition, drug targets, and side effects.
|
6. |
Harrison T et al. (2003) Erythrocyte G protein-coupled receptor signaling in malarial infection.
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7. |
Dallongeville J et al. (2003) The Gly16>Arg16 and Gln27>Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men.
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8. |
Odley A et al. (2004) Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling.
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9. |
Dishy V et al. (2004) Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo.
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10. |
Israel E et al. () Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial.
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11. |
Elefteriou F et al. (2005) Leptin regulation of bone resorption by the sympathetic nervous system and CART.
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12. |
Contopoulos-Ioannidis DG et al. (2005) Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes.
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13. |
Lönnqvist F et al. (1992) Lipolytic catecholamine resistance due to decreased beta 2-adrenoceptor expression in fat cells.
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14. |
Rasmussen SG et al. (2007) Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
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15. |
Rosenbaum DM et al. (2007) GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.
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16. |
Cherezov V et al. (2007) High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
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17. |
Cagliani R et al. (2009) Diverse evolutionary histories for beta-adrenoreceptor genes in humans.
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18. |
Nikolaev VO et al. (2010) Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation.
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19. |
Wilson RH et al. (2010) Evolutionary history of the ADRB2 gene in humans.
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20. |
Coureuil M et al. (2010) Meningococcus Hijacks a β2-adrenoceptor/β-Arrestin pathway to cross brain microvasculature endothelium.
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21. |
Rasmussen SG et al. (2011) Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.
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22. |
Rosenbaum DM et al. (2011) Structure and function of an irreversible agonist-β(2) adrenoceptor complex.
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23. |
Rasmussen SG et al. (2011) Crystal structure of the β2 adrenergic receptor-Gs protein complex.
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24. |
Chung KY et al. (2011) Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.
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25. |
Davare MA et al. (2001) A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2.
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26. |
Ni Y et al. (2006) Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.
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27. |
Oakey RJ et al. (1991) Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution.
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28. |
Szefler SJ et al. (1991) Plasma histamine, epinephrine, cortisol, and leukocyte beta-adrenergic receptors in nocturnal asthma.
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29. |
Yang-Feng TL et al. (1990) Chromosomal organization of adrenergic receptor genes.
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30. |
Emorine LJ et al. (1987) Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.
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31. |
Fraser CM et al. (1988) Site-directed mutagenesis of human beta-adrenergic receptors: substitution of aspartic acid-130 by asparagine produces a receptor with high-affinity agonist binding that is uncoupled from adenylate cyclase.
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32. |
Kobilka BK et al. (1987) cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
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33. |
Kobilka BK et al. () An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins.
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34. |
Sheppard JR et al. (1983) Chromosomal assignment of the gene for the human beta 2-adrenergic receptor.
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35. |
Turki J et al. (1995) Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.
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36. |
Reihsaus E et al. (1993) Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects.
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37. |
Dewar JC et al. (1997) The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families.
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38. |
Large V et al. (1997) Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function.
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39. |
Martinez FD et al. (1997) Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing.
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40. |
Hopes E et al. (1998) Association of glutamine 27 polymorphism of beta 2 adrenoceptor with reported childhood asthma: population based study.
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41. |
Krushkal J et al. (1998) Linkage and association of adrenergic and dopamine receptor genes in the distal portion of the long arm of chromosome 5 with systolic blood pressure variation.
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42. |
Luttrell LM et al. (1999) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
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43. |
Yamada K et al. (1999) Polymorphism in the 5'-leader cistron of the beta2-adrenergic receptor gene associated with obesity and type 2 diabetes.
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44. |
Rohrer DK et al. (1999) Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors.
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45. |
Maurice JP et al. (1999) Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
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46. |
Drysdale CM et al. (2000) Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness.
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47. |
Shenoy SK et al. (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.
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48. |
OMIM.ORG article
Omim 109690
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49. |
NCBI article
NCBI 154
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50. |
Wikipedia article
Wikipedia EN (Beta-2_adrenergic_receptor)
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Update: Aug. 14, 2020