Mitochondrial brown fat uncoupling protein 1
The UCP1 gene encodes a mitochondrial anion transporter which is involved in the regulation of energy consumption and heat production. Mutations can cause obesity wich follows a dominant model. Also synergistic effects with mutations in other genes have to be taken into account.
Genetests:
Related Diseases:
References:
1. |
Fletcher C et al. (1991) A multilocus linkage map of mouse chromosome 8.
|
2. |
Chouchani ET et al. (2016) Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.
|
3. |
Kong X et al. (2014) IRF4 is a key thermogenic transcriptional partner of PGC-1α.
|
4. |
Gerhart-Hines Z et al. (2013) The nuclear receptor Rev-erbα controls circadian thermogenic plasticity.
|
5. |
Tateishi K et al. (2009) Role of Jhdm2a in regulating metabolic gene expression and obesity resistance.
|
6. |
Berg F et al. (2006) The uncoupling protein 1 gene (UCP1) is disrupted in the pig lineage: a genetic explanation for poor thermoregulation in piglets.
|
7. |
Bernal-Mizrachi C et al. (2005) Vascular respiratory uncoupling increases blood pressure and atherosclerosis.
|
8. |
Nagai N et al. (2003) The -3826 A-->G variant of the uncoupling protein-1 gene diminishes postprandial thermogenesis after a high fat meal in healthy boys.
|
9. |
Echtay KS et al. (2002) Superoxide activates mitochondrial uncoupling proteins.
|
10. |
Echtay KS et al. (2000) Coenzyme Q is an obligatory cofactor for uncoupling protein function.
|
11. |
Urhammer SA et al. (1997) Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity.
|
12. |
Thomas SA et al. (1997) Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline.
|
13. |
Enerbäck S et al. (1997) Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese.
|
14. |
Clément K et al. (1996) Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity.
|
15. |
Lowell BB et al. () Development of obesity in transgenic mice after genetic ablation of brown adipose tissue.
|
16. |
Oppert JM et al. (1994) DNA polymorphism in the uncoupling protein (UCP) gene and human body fat.
|
17. |
Bouillaud F et al. (1986) Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein.
|
18. |
Bouillaud F et al. (1988) Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe.
|
19. |
Ridley RG et al. (1986) Complete nucleotide and derived amino acid sequence of cDNA encoding the mitochondrial uncoupling protein of rat brown adipose tissue: lack of a mitochondrial targeting presequence.
|
20. |
Jacobsson A et al. (1985) Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression.
|
21. |
Cassard AM et al. (1990) Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4.
|
22. |
Urhammer SA et al. (2000) Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young Danish subjects.
|
23. |
NCBI article
NCBI 7350
|
24. |
OMIM.ORG article
Omim 113730
|
25. |
Wikipedia article
Wikipedia EN (Thermogenin)
|
Update: Aug. 14, 2020