Syndecan-3
The SDC3 gene encodes a protein of the cytoskeleton which is involved in signal transduction. Mutations can cause obesity wich follows a dominant model. Also synergistic effects with mutations in other genes have to be taken into account.
Genetests:
Related Diseases:
References:
1. |
Carey DJ et al. (1992) Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan.
|
2. |
Spring J et al. (1994) Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family.
|
3. |
Reizes O et al. (2001) Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3.
|
4. |
Bobardt MD et al. (2003) Syndecan captures, protects, and transmits HIV to T lymphocytes.
|
5. |
Cornelison DD et al. (2004) Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration.
|
6. |
Strader AD et al. (2004) Mice lacking the syndecan-3 gene are resistant to diet-induced obesity.
|
7. |
Ha E et al. (2006) Positive association of obesity with single nucleotide polymorphisms of syndecan 3 in the Korean population.
|
8. |
de Witte L et al. (2007) Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1.
|
9. |
NCBI article
NCBI 9672
|
10. |
OMIM.ORG article
Omim 186357
|
11. |
Wikipedia article
Wikipedia EN (Syndecan-3)
|
Update: Aug. 14, 2020