Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
This TRPM7 gene resembles TRPM6 in its ability to channel divalent cations including magnesium, so it might play a role magnesium homeostasis. Genetic variations are associated with amyotrophic lateral sclerosis, too.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Schmitz C et al. (2005) The channel kinases TRPM6 and TRPM7 are functionally nonredundant. 
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| 2. |
Li M et al. (2006) Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.
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| 3. |
Schlingmann KP et al. (2007) TRPM6 and TRPM7--Gatekeepers of human magnesium metabolism.
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| 4. |
Li M et al. (2007) Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7.
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| 5. |
OMIM.ORG article Omim 605692
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| 6. |
Orphanet article Orphanet ID 159298
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| 7. |
NCBI article NCBI 54822
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| 8. |
Wikipedia article Wikipedia EN (TRPM7)
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