Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
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PPI-induced Hypomagnesemia

Some patients develop hypomagnesemia with long term treatment with proton pump inhibitors. Missense variants in the TRMP6 gene have ben identified to be responsible.

Systematic

Genetic alterations of drug tolerance
Coumarin resistance
Disturbances of cytochrome p450 system
Hepatitis C response to therapy
PPI-induced Hypomagnesemia
TRPM6

References:

1.

Fu CY et al. (2019) Increased risk of post-stroke epilepsy in Chinese patients with a TRPM6 polymorphism.

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2.

Hess MW et al. (2017) Common single nucleotide polymorphisms in transient receptor potential melastatin type 6 increase the risk for proton pump inhibitor-induced hypomagnesemia: a case-control study.

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3.

Saraç M et al. (2016) Magnesium-permeable polymorphisms in patients with meningomyelocele.

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4.

Hruby A et al. (2013) Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies.

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5.

Okumus S et al. (2013) Association transient receptor potential melastatin channel gene polymorphism with primary open angle glaucoma.

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6.

Song Y et al. (2009) Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women.

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7.

William JH et al. (2016) Proton-pump inhibitor-induced hypomagnesemia: Current research and proposed mechanisms.

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8.

Park CH et al. (2014) The association between the use of proton pump inhibitors and the risk of hypomagnesemia: a systematic review and meta-analysis.

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9.

Walder RY et al. (1997) Familial hypomagnesemia maps to chromosome 9q, not to the X chromosome: genetic linkage mapping and analysis of a balanced translocation breakpoint.

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10.

Schlingmann KP et al. (2002) Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.

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11.

Walder RY et al. (2002) Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia.

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12.

Chubanov V et al. (2004) Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.

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13.

Walder RY et al. (2009) Mice defective in Trpm6 show embryonic mortality and neural tube defects.

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14.

Farooqi AA et al. (2011) TRPM channels: same ballpark, different players, and different rules in immunogenetics.

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15.

Lainez S et al. (2014) New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemia.

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Update: Nov. 3, 2022
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