Some patients develop hypomagnesemia with long term treatment with proton pump inhibitors. Missense variants in the TRMP6 gene have ben identified to be responsible.
Genetic alterations of drug tolerance | ||||
Coumarin resistance | ||||
Disturbances of cytochrome p450 system | ||||
Hepatitis C response to therapy | ||||
PPI-induced Hypomagnesemia | ||||
TRPM6 | ||||
1. |
Fu CY et al. (2019) Increased risk of post-stroke epilepsy in Chinese patients with a TRPM6 polymorphism. |
3. |
Saraç M et al. (2016) Magnesium-permeable polymorphisms in patients with meningomyelocele. |
5. |
Okumus S et al. (2013) Association transient receptor potential melastatin channel gene polymorphism with primary open angle glaucoma. |
6. |
Song Y et al. (2009) Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women. |
7. |
William JH et al. (2016) Proton-pump inhibitor-induced hypomagnesemia: Current research and proposed mechanisms. |
8. |
Park CH et al. (2014) The association between the use of proton pump inhibitors and the risk of hypomagnesemia: a systematic review and meta-analysis. |
9. |
Walder RY et al. (1997) Familial hypomagnesemia maps to chromosome 9q, not to the X chromosome: genetic linkage mapping and analysis of a balanced translocation breakpoint. |
10. |
Schlingmann KP et al. (2002) Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. |
11. |
Walder RY et al. (2002) Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. |
12. |
Chubanov V et al. (2004) Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. |
13. |
Walder RY et al. (2009) Mice defective in Trpm6 show embryonic mortality and neural tube defects. |
14. |
Farooqi AA et al. (2011) TRPM channels: same ballpark, different players, and different rules in immunogenetics. |
15. |
Lainez S et al. (2014) New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemia. |