Hyperzincemia and hypercalprotectinemia is an autosomal dominant autoinflammatory disease caused by mutations of the PSTPIP1. Like PAPA syndrome pyogenic arthritis, pyoderma gangrenosum, and acne are found in addition to elevated zinc levels in plasma.
|Hereditary metabolic diseases|
|Coenzyme Q10 deficiency|
|Congenital disorder of glycosylation|
|Disorders of cobalamin metabolism|
|Disorders of iron metabolism|
|Disorders of urate metabolism|
|Disturbances in phosphate metabolism|
|Disturbances of glucose metabolism|
|Hereditary disorders protein metabolism|
|Hereditary lipid disorders|
|Hyperzincemia and hypercalprotectinemia|
|Lysosomal storage disease|
|Methionine adenosyltransferase deficiency|
|Urea cycle disorders|
Smith JC et. al. (1976) Elevated plasmz zinc: a heritable anomaly.
Hambidge KM et. al. (1985) Hyperzincemia in a patient with pyoderma gangrenosum.
Failla ML et. al. (1982) Characterization of zinc-binding proteins of plasma in familial hyperzincemia.
Sampson B et. al. (1997) A case of hyperzincemia with functional zinc depletion: a new disorder?
Saito Y et. al. (2002) Hyperzincemia with systemic inflammation: a heritable disorder of calprotectin metabolism with rheumatic manifestations?
Sampson B et. al. (2002) Hyperzincaemia and hypercalprotectinaemia: a new disorder of zinc metabolism.
Stewart AJ et. al. (2003) Interdomain zinc site on human albumin.