Autoimmune polyendokrinopathy is a group of disorders characterized by insuffisiencies in several endocrine systems. The pathogenesis is due to dysregulation of the immune system leading to autoantibodies or other autoimmune phenomena.
Autoimmune polyendokrinopathy syndrome can be divided into 4 groups:
Type 1 Chronic candidiasis, chronic hypoparathyroidism, autoimmune adrenocortical insufficiency (at least two present).
Type 2 Autoimmune adrenocortical insufficiency autoimmune thyroid diseases and/or type 1 diabetes mellitus (adrenocortical insufficiency must always be present)
Type 3 Thyroid autoimmune diseases and other autoimmune diseases (excluding autoimmune adrenocortical insufficiency, hypoparathyroidism, chronic candidiasis).
Type 4 Two or more organ-specific autoimmune diseases (which do not fall into type 1, 2, or 3)
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OMIM.ORG article Omim 304790 |