Various genetic alterations at the glucocorticoid receptor locus can trigger hight blood pressure. Among them the most severe form, the glucocorticoid resistance, which is associated with hyperaldosteronism, and also various polymorphisms can contribute to hypertension in metabolic syndrome and endocrinological disorders.
Monogenic hypertension | ||||
Apparent mineralocorticoid excess | ||||
Glucocorticoid triggered hypertension | ||||
NR3C1 | ||||
Hyperaldosteronism | ||||
Hypertension and brachydactyly syndrome | ||||
Liddle syndrome | ||||
Pseudohypoaldosteronism | ||||
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Nicolaides NC et al. (2015) Chrousos syndrome: from molecular pathogenesis to therapeutic management. |
2. |
Lin S et al. (2014) Interaction between occupational stress and GR gene polymorphisms on essential hypertension among railway workers. |
3. |
Moreira RP et al. (2013) Modulatory effect of BclI GR gene polymorphisms on the obesity phenotype in Brazilian patients with Cushing's disease. |
4. |
Islam A et al. (2012) Glucocorticoid receptor density correlates with health risk factors and insulin resistance in Caucasian and African American subjects. |
5. |
OMIM.ORG article Omim 605115 |