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Age-related macula degeneration 01

Age-related macula degeneration is a hereditary immunological disorder of progressive visual impairment that is associated with many different genes.

Systematic

Macular degeneration
Age-related macula degeneration 01
APOE
ARMS2
C2
C3
CFH
CFHR1
CFHR3
KCNT2
Early-onset macula degeneration

References:

1.

Klein R et al. (2004) The epidemiology of age-related macular degeneration.

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2.

Tamer C et al. (2007) Serum dehydroepiandrosterone sulphate level in age-related macular degeneration.

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None (2006) Age-related macular degeneration.

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Imamura Y et al. (2006) Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration.

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11.

Ethen CM et al. (2005) Declines in arrestin and rhodopsin in the macula with progression of age-related macular degeneration.

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None (2004) Current concepts in the pathogenesis of age-related macular degeneration.

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Fisher SA et al. (2007) Case-control genetic association study of fibulin-6 (FBLN6 or HMCN1) variants in age-related macular degeneration (AMD).

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15.

Jonas JB et al. (2004) Intravitreal reinjection of triamcinolone for exudative age-related macular degeneration.

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Grisanti S et al. (2004) Expression of endoglin in choroidal neovascularization.

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17.

Scholl HP et al. (2004) What is lost by digitizing stereoscopic fundus color slides for macular grading in age-related maculopathy and degeneration?

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18.

Axer-Siegel R et al. (2004) Association of neovascular age-related macular degeneration and hyperhomocysteinemia.

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Iyengar SK et al. (2004) Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration.

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20.

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21.

Schultz DW et al. (2003) Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family.

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22.

Heckenlively JR et al. (2003) Mouse model of subretinal neovascularization with choroidal anastomosis.

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23.

Hahn P et al. (2003) Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane.

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24.

Danciger M et al. (2003) A strong and highly significant QTL on chromosome 6 that protects the mouse from age-related retinal degeneration.

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25.

Klein R et al. (2003) Association of emphysema, gout, and inflammatory markers with long-term incidence of age-related maculopathy.

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De S et al. (2007) Human retinal pigment epithelium cell changes and expression of alphaB-crystallin: a biomarker for retinal pigment epithelium cell change in age-related macular degeneration.

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27.

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Fowler BJ et al. (2014) Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.

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29.

Arakawa S et al. (2011) Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.

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Kaneko H et al. (2011) DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.

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31.

Kondo N et al. (2010) Additional evidence to support the role of a common variant near the complement factor I gene in susceptibility to age-related macular degeneration.

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Takeda A et al. (2009) CCR3 is a target for age-related macular degeneration diagnosis and therapy.

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Li C et al. (2007) Biochemical alterations in the retinas of very low-density lipoprotein receptor knockout mice: an animal model of retinal angiomatous proliferation.

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Sivaprasad S et al. (2007) Estimation of systemic complement C3 activity in age-related macular degeneration.

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40.

Kamei M et al. (2007) Scavenger receptors for oxidized lipoprotein in age-related macular degeneration.

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41.

Bhosale P et al. (2007) Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula.

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42.

Tan JS et al. (2007) Statins and the long-term risk of incident age-related macular degeneration: the Blue Mountains Eye Study.

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43.

Schaumberg DA et al. (2007) High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in women.

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Chakravarthy U et al. (2007) Cigarette smoking and age-related macular degeneration in the EUREYE Study.

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45.

Boekhoorn SS et al. (2007) Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder.

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Gupta SK et al. (2007) Prevalence of early and late age-related macular degeneration in a rural population in northern India: the INDEYE feasibility study.

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47.

Kim DH et al. (2007) Strategies for silencing human disease using RNA interference.

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48.

Decanini A et al. (2007) Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration.

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Tan JS et al. (2007) Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study.

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50.

Seddon JM et al. (2003) A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions.

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51.

Kanda A et al. (2007) A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.

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52.

Schaumberg DA et al. (2007) A prospective study of 2 major age-related macular degeneration susceptibility alleles and interactions with modifiable risk factors.

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53.

Dewan A et al. (2006) HTRA1 promoter polymorphism in wet age-related macular degeneration.

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54.

Conley YP et al. (2006) CFH, ELOVL4, PLEKHA1 and LOC387715 genes and susceptibility to age-related maculopathy: AREDS and CHS cohorts and meta-analyses.

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55.

Schmidt S et al. (2006) Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration.

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56.

Rivera A et al. (2005) Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk.

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57.

Fisher SA et al. (2005) Meta-analysis of genome scans of age-related macular degeneration.

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58.

Kenealy SJ et al. (2004) Linkage analysis for age-related macular degeneration supports a gene on chromosome 10q26.

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59.

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Jakobsdottir J et al. (2005) Susceptibility genes for age-related maculopathy on chromosome 10q26.

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61.

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62.

Borrillo JL et al. (2003) Surgical ablation of retinal angiomatous proliferation.

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63.

Majewski J et al. (2003) Age-related macular degeneration--a genome scan in extended families.

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Doyle SL et al. (2012) NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components.

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65.

Allikmets R et al. (2009) Geographic atrophy in age-related macular degeneration and TLR3.

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66.

Edwards AO et al. (2009) Geographic atrophy in age-related macular degeneration and TLR3.

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67.

Yang Z et al. (2008) Toll-like receptor 3 and geographic atrophy in age-related macular degeneration.

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68.

Kleinman ME et al. (2008) Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.

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69.

Tarallo V et al. (2012) DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.

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Goverdhan SV et al. (2005) Association of HLA class I and class II polymorphisms with age-related macular degeneration.

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73.

Maller J et al. (2006) Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration.

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74.

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79.

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80.

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81.

None (2002) Retinal angiomatous proliferation in age-related macular degeneration.

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82.

Krzystolik MG et al. (2002) Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment.

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83.

Dithmar S et al. (2001) Murine high-fat diet and laser photochemical model of basal deposits in Bruch membrane.

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84.

Weeks DE et al. (2001) Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions.

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85.

Yannuzzi LA et al. (2001) Retinal angiomatous proliferation in age-related macular degeneration.

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86.

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87.

Weeks DE et al. (2000) A full genome scan for age-related maculopathy.

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88.

Smith RS et al. (2000) The bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization.

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89.

Klein ML et al. (1998) Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q.

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90.

Allikmets R et al. (1997) Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration.

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Seddon JM et al. (1997) Familial aggregation of age-related maculopathy.

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92.

Heiba IM et al. (1994) Sibling correlations and segregation analysis of age-related maculopathy: the Beaver Dam Eye Study.

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93.

None (1966) Dystrophy of the macula.

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94.

Malek G et al. (2005) Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.

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95.

Fritsche LG et al. (2013) Seven new loci associated with age-related macular degeneration.

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96.

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97.

Fritsche LG et al. (2008) Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA.

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98.

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