Fructose intolerance is an autosomal recessive disorder caused by mutations of the aldolase B gene. The disease is characterized by fructosemia and hypoglycemia trat trigger intermittend symptoms such a vomiting. In the the clinical course, liver damage may occur.
The prevalence is estimated between 1:23,000 and 1:130.000.[Error: Macro 'ref' doesn't exist]
As aldolase B is deficient in fructosemia, dietary fructose is metabolized by aldolase A that shows a much slower catabolic rate. Consequentially, fructose inhibits glycolysis and glyconeogenesis (gluconeogenesis) and hypoglycemia may occur. Intermittend cerebral symptoms and chronic liver damage ensue.
Proximal tubular damage syndrome | |
Fructose intolerance causes unspecific proximal tubular damage called renotubular Fanconi syndrome. |
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