Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Hereditary susceptibility to infections

This group includes hereditary genetic changes that affect the susceptibility to infectious diseases. Those disorders include general disturbances of the infectious defense mechanisms. Those disturbances result in a general susceptibility to all or a wider group of infections. There are also genetic variations that specifically affect resistance or susceptibility to a specific infectious agent.

Systematic

Hereditary diseases
Hereditary broncho-pulmonary disease
Hereditary cardiac disease
Hereditary dermatological disorders
Hereditary diseases of the hematopoetic system and coagulopathies
Hereditary endocrinological diseases
Hereditary immunological disorders
Hereditary kidney diseases
Hereditary liver disease
Hereditary malformations
Hereditary metabolic diseases
Hereditary musculoskeletal diseases
Hereditary neurological disorders
Hereditary ocular disease and visual impairment
Hereditary otorhinolaryngological disorders
Hereditary pancreatic disease
Hereditary susceptibility to infections
Disorders of mRNA editing
APOBEC1
APOBEC2
APOBEC3A
APOBEC3B
APOBEC3C
APOBEC3D
APOBEC3F
APOBEC3G
APOBEC3H
APOBEC4
HIV resistance
CCR5
CXCR1
HIV1 susceptibility
IL10
IRAK4 deficiency
IRAK4
Invasive pneumococcal disease
Invasive pneumococcal disease 1
IRAK4
Invasive pneumococcal disease 2
IKBKG
Invasive pneumococcal disease 3
TIRAP
Measles infection susceptibility
CD46
Meningococcal infection susceptibility
C3
C5
C7
C8A
C8B
C8G
C9
CD46
CFB
CFD
CFH
CFP
Resistance to trypanosoma brucei
APOL1
Septic shock
TNF
Susceptibility to bacteremia 1
TIRAP
Susceptibility to malaria
FCGR2A
FCGR2B
TNF
Susceptibility to mycobacterial diseases
TIRAP
X-linked mendelian susceptibility to mycobacterial diseases due to IKBKG deficiency
IKBKG
Susceptibility to pseudomonas infection
FCGR2A
X-linked mendelian susceptibility to mycobacterial diseases due to IKBKG deficiency
IKBKG
Hereditary tumors
Hereditary vascular disease
Hypertension

References:

1.

Sardinha JF et al. () Genetic risk factors for human susceptibility to infections of relevance in dermatology.

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Update: May 9, 2019