MODY1 diabetes

MODY1 is an autosomal dominant early-onset type 2 diabetes caused by mutations of the HNF4A gene.

Epidemiology

There are only some few cases reported throughout the word.

Test Strategy

The diagnostic procedures generally are the same for all types of MODY diabetes.

Pathogenesis

This gene is in the same signaling cascade as TCF1, the gene where defects are responsible for MODY3. Therefore the pathogenesis and clinical expression are similar.

Systematic

MODY diabetes
	MODY1 diabetes
		HNF4A
	MODY10 diabetes
	MODY11 diabetes
	MODY12 diabetes
	MODY13 diabetes
	MODY14 diabetes
	MODY2 diabetes
	MODY3 diabetes
	MODY4 diabetes
	MODY5 diabetes
	MODY6 diabetes
	MODY7 diabetes
	MODY8 diabetes
	MODY9 diabetes

References:

1.	Fajans SS et al. (2001) Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.

2.	Weng J et al. (2002) Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus.

3.	OMIM.ORG article Omim 125850