Glomerulonephritis is a collection of disorders with different pathogeneses and histomorphologies whose common denominator is inflammation of the glomeruli, the fitration barrier of the kidney. Often glomerulonephrites are caused by immunological disturbances and therefore increasingly genetic disorders are found to be essential for its development.
Basic symptoms are proteinuria and glomerular hematuria. Theres two main symptoms underly the clinical classifiaction into nephrotic and nephritic kidney disease.
Histomorphology allows a more accurate diagnosis and classification into subtypes that differ by histomorphology. Histomorphological studies also allow immunehistochenistry which comes close to a pathogenetic classification.
Most recent genetic fidings allow an even deeper pathognetic classification.
1. |
Julian BA et al. (1988) IgA nephropathy, the most common glomerulonephritis worldwide. A neglected disease in the United States? |
2. |
Hsu SI et al. (2000) Evidence for genetic factors in the development and progression of IgA nephropathy. |
3. |
Gharavi AG et al. (2000) IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23. |
4. |
Hiki Y et al. (2001) Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy. |
5. |
Allen AC et al. (2001) Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients. |
6. |
Takei T et al. (2002) Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy. |
7. |
Donadio JV et al. (2002) IgA nephropathy. |
8. |
Yoon HJ et al. (2003) Association of the CD14 gene -159C polymorphism with progression of IgA nephropathy. |
9. |
Song J et al. (2003) Gender specific association of aldosterone synthase gene polymorphism with renal survival in patients with IgA nephropathy. |
10. |
Wang J et al. (2004) Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy. |
11. |
Bisceglia L et al. (2006) Genetic heterogeneity in Italian families with IgA nephropathy: suggestive linkage for two novel IgA nephropathy loci. |
12. |
Suzuki H et al. (2008) IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1. |
13. |
Piscione TD et al. (2011) Genetics of proteinuria: an overview of gene mutations associated with nonsyndromic proteinuric glomerulopathies. |
14. |
Miller EC et al. (2012) Autoantibody stabilization of the classical pathway C3 convertase leading to C3 deficiency and Neisserial sepsis: C4 nephritic factor revisited. |
15. |
None (1989) Familial cases of Berger's disease and anaphylactoid purpura: more frequent than previously thought. |
16. |
None (1987) The commonest glomerulonephritis in the world: IgA nephropathy. |
17. |
Yoshida H et al. (1995) Role of the deletion of polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy. |
18. |
Asamoah A et al. (1987) A major gene model for the familial aggregation of plasma IgA concentration. |
19. |
Coppo R et al. (1986) Dietary gluten and primary IgA nephropathy. |
20. |
Julian BA et al. (1985) Familial IgA nephropathy. Evidence of an inherited mechanism of disease. |
21. |
Jennette JC et al. (1985) Low incidence of IgA nephropathy in blacks. |
22. |
None (1969) IgA glomerular deposits in renal disease. |
23. |
Sabatier JC et al. (1979) Mesangial IgA glomerulonephritis in HLA-identical brothers. |
24. |
McCoy RC et al. (1974) IgA nephropathy. |
25. |
Croker BP et al. (1983) IgA nephropathy. Correlation of clinical and histologic features. |
27. |
Berthoux FC et al. (1978) HLA-Bw35 and mesangial IgA glomerulonephritis. |
28. |
Brettle R et al. (1978) Mesangial IgA glomerulonephritis and HLA antigens. |
29. |
Tolkoff-Rubin NE et al. (1978) IGA nephropathy in HLA-identical siblings. |
30. |
Katz A et al. (1980) Family study in IgA nephritis: the possible role of HLA antigens. |
31. |
Tomana M et al. (1997) Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. |
32. |
Segerer S et al. (1999) Expression of the C-C chemokine receptor 5 in human kidney diseases. |
33. |
Pei Y et al. (1997) Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. |
34. |
Levy M et al. (1986) H deficiency in two brothers with atypical dense intramembranous deposit disease. |
35. |
Brai M et al. (1988) Combined homozygous factor H and heterozygous C2 deficiency in an Italian family. |
36. |
Vogt BA et al. (1995) Inherited factor H deficiency and collagen type III glomerulopathy. |
37. |
Høgåsen K et al. (1995) Hereditary porcine membranoproliferative glomerulonephritis type II is caused by factor H deficiency. |
38. |
Ault BH et al. (1997) Human factor H deficiency. Mutations in framework cysteine residues and block in H protein secretion and intracellular catabolism. |
39. |
Sánchez-Corral P et al. (2000) Molecular basis for factor H and FHL-1 deficiency in an Italian family. |
40. |
None (2000) Factor H and the pathogenesis of renal diseases. |
41. |
Pickering MC et al. (2002) Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. |
42. |
Hegasy GA et al. (2002) The molecular basis for hereditary porcine membranoproliferative glomerulonephritis type II: point mutations in the factor H coding sequence block protein secretion. |
45. |
Licht C et al. (2006) Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II). |
46. |
Servais A et al. (2007) Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome. |
47. |
Saunders RE et al. (2006) An interactive web database of factor H-associated hemolytic uremic syndrome mutations: insights into the structural consequences of disease-associated mutations. |
48. |
McRae JL et al. (2002) Location and structure of the human FHR-5 gene. |
49. |
Zheng F et al. (1999) Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice. |
50. |
Scolari F et al. (1999) Familial clustering of IgA nephropathy: further evidence in an Italian population. |
51. |
Berry PL et al. (1981) Membranoproliferative glomerulonephritis in two sibships. |
52. |
Mandalenakis N et al. (1971) Lobular glomerulonephritis and membranoproliferative glomerulonephritis: a clinical and pathologic study based on renal biopsies. |
53. |
Habib R et al. () Idiopathic membranoproliferative glomerulonephritis in children. Report of 105 cases. |
54. |
Stutchfield PR et al. (1986) X-linked mesangiocapillary glomerulonephritis. |
55. |
Strife CF et al. (1977) Membranoproliferative glomerulonephritis with disruption of the glomerular basement membrane. |
56. |
Appel GB et al. (2005) Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. |
57. |
None (2002) Complement in glomerulonephritis. |
58. |
Fijen CA et al. (1996) Heterozygous and homozygous factor H deficiency states in a Dutch family. |
59. |
Wyatt RJ et al. (1982) Partial H (beta 1H) deficiency and glomerulonephritis in two families. |
60. |
McRae JL et al. (2001) Human factor H-related protein 5 (FHR-5). A new complement-associated protein. |
61. |
Rougier N et al. (1998) Human complement factor H deficiency associated with hemolytic uremic syndrome. |
62. |
OMIM.ORG article Omim 137940 |
63. |
Orphanet article Orphanet ID 280569 |
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Wikipedia article Wikipedia EN (Glomerulonephritis) |