Arteriosclerosis

Arteriosclerosis is a vascular disease in the arterial system that causes many organ disorders including myocardial infarction, cerebral infarction etc.

Test Strategy

There are lot of investigation developed that allow us to determine localization and extention of arteriosclerotic lesions. But to clarify the pathogenesis only risk factors can be established.

Pathogenesis

The pathogenesis is not fully understood. There are several risk factors known until now: these include environmantal factors (smoking, diet), thrombotic and lipid disorders.

Systematic

Hereditary vascular disease
	Arteriosclerosis
		APOB
		APOE
		HABP2
		LDLR
		LPA
		MTHFR
		PON1
		SLC3A1
	Diabetic microangiopathy 4
	Hereditary Angioedema
	Hereditary lymphedema
	STING-associated vasculopathy with onset in infancy
	Sneddon syndrome
	Susceptibility to arteriovenous malformations of the brain
	Thromboembolic diseases
	Vascular calcification
	Vasculitis due to ADA2 deficiency

References:

1.	Lusis AJ et al. (2004) Genetic basis of atherosclerosis: part I: new genes and pathways.

2.	Kluijtmans LA et al. (1996) Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

3.	Hingorani AD et al. (1999) A common variant of the endothelial nitric oxide synthase (Glu298-->Asp) is a major risk factor for coronary artery disease in the UK.

4.	OMIM.ORG article Omim 208060

5.	Wikipedia article Wikipedia EN (Arteriosclerosis)