Molecular genetic analysis (gene test): Phospholipase A2 receptor 1 (PLA2R1)

PLA2R1
604939

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Phospholipase A2 receptor 1

Scientific background:

Summary: The pathogenetic role of this gene remains to be elucidated.

Methodology:

	research test	Method		Genomic sequencing of the entire coding region
		Turn-around time		25 working days
		Effort		25 working days
		Specimen		DNA\|RNA
		Quality assessment		Internal quality control only
	All known and new missense, nonsense and splice mutations can be detected.
	research test	Method		Genomic sequencing of the entire coding region
		Turn-around time		25 working days
		Effort		25 working days
		Specimen		DNA\|RNA
		Quality assessment		Internal quality control only
	All known and new missense, nonsense and splice mutations can be detected.

Systematic link table:

Membranoproliferative glomerulonephritis
	C1QB
	CFH
	CFHR5
	MTHFR
	PLA2R1

Literature:

Ancian P et al. (1995) The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization.
Beck LH et al. (2009) M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.