Scientific background:

Summary: The gene KLF11 encodes a zinc finger transcription factor involved in regulation of insulin secretetion. Missensemutations in this gene might cause autosomal dominant MODY7 diabetes.

Methodology:

	clinical test	Method		Genomic sequencing of the entire coding region
		Turn-around time		25 working days
		Effort		little
		Specimen		DNA
		Quality assessment		Internal quality control only
	All known and new missense, nonsense and splice mutations can be detected.
	clinical test	Method		Carrier testing
		Turn-around time		5 working days
		Effort		little
		Specimen		DNA
		Quality assessment		Internal quality control only
	The test is only specific about the mutation already known in this kindred.

Literature: 

Neve B et al. (2005) Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.