Clinical feature: 

Definition: Glomerulosclerosis describes histomorphological alterations of the kidney characterized by glomerular fibrosis and scars. This is the common end point in several pathological processes affecting the glomerulus. It may occur focal, only some glomeruli altered, and segmental, only parts of the glomerulus affected.

Literature: 

Kao WH et al. (2008) MYH9 is associated with nondiabetic end-stage renal disease in African Americans.
Kopp JB et al. (2008) MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis.