Clinical feature: 

Definition: Arteriosclerosis is a vascular disease in the arterial system that causes many organ disorders including myocardial infarction, cerebral infarction etc.

Pathogenesis: The pathogenesis is not fully understood. There are several risk factors known until now: these include environmantal factors (smoking, diet), thrombotic and lipid disorders.

Diagnostics: 

Strategy: There are lot of investigation developed that allow us to determine localization and extention of arteriosclerotic lesions. But to clarify the pathogenesis only risk factors can be established.

Literature: 

Hingorani AD et al. (1999) A common variant of the endothelial nitric oxide synthase (Glu298-->Asp) is a major risk factor for coronary artery disease in the UK.
Kluijtmans LA et al. (1996) Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.
Lusis AJ et al. (2004) Genetic basis of atherosclerosis: part I: new genes and pathways.