Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Interferon gamma

Das INFG-Gen kodiert ein Zytokin, das Interferon gamma welches für die Reifung von Th1 CD4 T-Zellen verantwortlich ist und Makrophagen zu mikrobiziden Abtötung intrazellulärer Mikroben stimuliert, Dies hat insbesondere eine Bedeutung für die Abwehr von Mykobakterien.

Gentests:

Klinisch Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Forschung Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Immundefekt 69
IFNG
AIDS-Pogression
IFNG
Hepatitis C-Therapieansprechbarkeit
IFNG
Isolierter kongenitaler ACTH-Mangel
TBX19
Tuberöse Sklerose 2
IFNG
TSC2

Referenzen:

1.

Rossouw M et al. (2003) Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene.

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2.

Huang Y et al. (2007) A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection.

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3.

Cooke GS et al. (2006) Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis.

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4.

Chang S et al. (2005) Histone hyperacetylated domains across the Ifng gene region in natural killer cells and T cells.

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5.

Spilianakis CG et al. (2005) Interchromosomal associations between alternatively expressed loci.

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6.

Svensson A et al. (2005) Protective immunity to genital herpes simplex [correction of simpex] virus type 2 infection is mediated by T-bet.

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7.

Koh KP et al. (2004) T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase.

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8.

Dufour C et al. (2004) Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population.

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9.

An P et al. (2003) A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals.

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10.

Barton ES et al. (2007) Herpesvirus latency confers symbiotic protection from bacterial infection.

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11.

Messi M et al. (2003) Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes.

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12.

Dabora SL et al. (2002) Association between a high-expressing interferon-gamma allele and a lower frequency of kidney angiomyolipomas in TSC2 patients.

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13.

Ben-Asouli Y et al. (2002) Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR.

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14.

Szabo SJ et al. (2002) Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.

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15.

Cavet J et al. (2001) Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation.

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16.

Binder GK et al. (2001) Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons.

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17.

Zohlnhöfer D et al. (2001) Transcriptome analysis reveals a role of interferon-gamma in human neointima formation.

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18.

Takayanagi H et al. (2000) T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.

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19.

Schoenborn JR et al. (2007) Regulation of interferon-gamma during innate and adaptive immune responses.

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20.

Bai Y et al. (2008) Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.

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21.

Kosaka H et al. (2008) Interferon-gamma is a therapeutic target molecule for prevention of postoperative adhesion formation.

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22.

Pacheco AG et al. (2008) IFNG +874T/A, IL10 -1082G/A and TNF -308G/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study.

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23.

King VL et al. (2009) Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture.

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24.

Baldridge MT et al. (2010) Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection.

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25.

Zaidi MR et al. (2011) Interferon-γ links ultraviolet radiation to melanomagenesis in mice.

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26.

Zielinski CE et al. (2012) Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.

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27.

Braumüller H et al. (2013) T-helper-1-cell cytokines drive cancer into senescence.

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28.

Barin JG et al. (2013) Fatal eosinophilic myocarditis develops in the absence of IFN-γ and IL-17A.

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29.

Sa Q et al. (2015) Cutting Edge: IFN-γ Produced by Brain-Resident Cells Is Crucial To Control Cerebral Infection with Toxoplasma gondii.

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30.

Iijima N et al. (2016) Access of protective antiviral antibody to neuronal tissues requires CD4 T-cell help.

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31.

Arbore G et al. (2016) T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

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32.

Filiano AJ et al. (2016) Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour.

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33.

Kerner G et al. (2020) Inherited human IFN-γ deficiency underlies mycobacterial disease.

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34.

Nathan CF et al. (1983) Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

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35.

Fields PE et al. (2002) Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation.

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36.

Justice MJ et al. (1990) A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.

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37.

None (1977) The status of interferon.

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38.

Creagan RP et al. (1975) Somatic cell genetic analysis of the interferon system.

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39.

Shimizu A et al. (1992) A molecular genetic linkage map of mouse chromosome 10, including the Myb, S100b, Pah, Sl, and Ifg genes.

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40.

Tzoneva M et al. (1988) Selective immunodeficiency with defect in interferon-gamma induction in two sibs with recurrent infections.

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41.

Luster AD et al. () Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins.

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42.

Lipinski M et al. (1980) Natural killer and killer cell activities in patients with primary immunodeficiencies or defects in immune interferon production.

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43.

Mantei N et al. (1980) The nucleotide sequence of a cloned human leukocyte interferon cDNA.

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44.

Blalock JE et al. (1980) Human leukocyte interferon: structural and biological relatedness to adrenocorticotropic hormone and endorphins.

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45.

Maeda S et al. (1980) Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon.

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46.

Devos R et al. (1982) Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells.

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47.

Yip YK et al. (1982) Purification of two subspecies of human gamma (immune) interferon.

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48.

Gray PW et al. (1982) Structure of the human immune interferon gene.

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49.

Naylor SL et al. (1983) Human immune interferon gene is located on chromosome 12.

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50.

Teles RM et al. (2013) Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.

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51.

Trent JM et al. (1982) Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization.

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52.

Knight E et al. (1980) Human fibroblast interferon: amino acid analysis and amino terminal amino acid sequence.

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53.

Zoon KC et al. (1980) Amino terminal sequence of the major component of human lymphoblastoid interferon.

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54.

Zimonjic DB et al. (1995) Mapping of the immune interferon gamma gene (IFNG) to chromosome band 12q14 by fluorescence in situ hybridization.

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55.

Bureau JF et al. (1995) The gene coding for interferon-gamma is linked to the D12S335 and D12S313 microsatellites and to the MDM2 gene.

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56.

Diaz MO et al. (1993) Nomenclature of the human interferon genes.

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57.

Tsubota K et al. (1999) Regulation of human leukocyte antigen expression in human conjunctival epithelium.

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58.

Pravica V et al. (1999) In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene.

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59.

Diefenbach A et al. (1999) Requirement for type 2 NO synthase for IL-12 signaling in innate immunity.

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60.

Awad M et al. (1999) CA repeat allele polymorphism in the first intron of the human interferon-gamma gene is associated with lung allograft fibrosis.

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61.

Bream JH et al. (2000) Polymorphisms of the human IFNG gene noncoding regions.

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62.

White AC et al. (2000) Interferon-gamma expression in jejunal biopsies in experimental human cryptosporidiosis correlates with prior sensitization and control of oocyst excretion.

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63.

Khani-Hanjani A et al. (2000) Association between dinucleotide repeat in non-coding region of interferon-gamma gene and susceptibility to, and severity of, rheumatoid arthritis.

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64.

Pravica V et al. (2000) A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production.

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65.

Badovinac VP et al. (2000) Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma.

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Update: 14. August 2020
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