Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel

Niedrigaffiner IgG-FcRezeptor 2-b

Das FCGR2B-Gen kodiert eine Komponente eines Immunglobulin-Rezeptors. Genetische Varianten sind für eine Anfälligkeit für systemischen Lupus erythematodes und verschiedene Infektionen verantwortlich.

Gentests:

Klinisch Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Forschung Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Suszeptibilität für Malaria
FCGR2A
FCGR2B
TNF

Referenzen:

1.

Li F et al. (2011) Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies.

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2.

Machado LR et al. (2012) Evolutionary history of copy-number-variable locus for the low-affinity Fcγ receptor: mutation rate, autoimmune disease, and the legacy of helminth infection.

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3.

Engelhardt W et al. (1990) Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II.

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4.

Callanan MB et al. (2000) The IgG Fc receptor, FcgammaRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma.

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5.

Ravetch JV et al. (2000) Immune inhibitory receptors.

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6.

Samuelsson A et al. (2001) Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor.

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7.

Zhu D et al. (2002) A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation.

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8.

Kyogoku C et al. (2002) Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility.

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9.

Su K et al. (2004) A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus.

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10.

Iwasaki M et al. (2005) Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model.

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11.

Hitomi Y et al. (2004) CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B.

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12.

McGaha TL et al. (2005) Restoration of tolerance in lupus by targeted inhibitory receptor expression.

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13.

Blank MC et al. (2005) Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus.

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14.

Kono H et al. (2005) FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling.

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15.

Floto RA et al. (2005) Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts.

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16.

Okazaki T et al. (2005) Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice.

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17.

Clatworthy MR et al. (2007) Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.

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18.

Willcocks LC et al. (2010) A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.

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19.

Mueller M et al. (2013) Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.

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20.

Wang TT et al. (2015) Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy.

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Update: 17. Oktober 2019