Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Macrophagen-Migrations-Hemmungsfaktor

Das MIF-Gen kodiert ein Zytokin, welches für die Regulation von Immunreaktion und Inflammation verantwortlich ist. Genetische Varianten beeinflussen die Neigung zu juveniler Arthritis.

Gentests:

Klinisch Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Forschung Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Systemische idiopathische juvenile Arthritis
IL6
LACC1
MIF

Referenzen:

1.

Pastrana DV et al. (1998) Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor.

external link
2.

Miller EJ et al. (2008) Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.

external link
3.

Arjona A et al. (2007) Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion.

external link
4.

Bernhagen J et al. (2007) MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment.

external link
5.

Wang B et al. (2006) Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses.

external link
6.

Amin MA et al. (2003) Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase.

external link
7.

De Benedetti F et. al. (2003) Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis.

external link
8.

Donn R et. al. (2002) Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis.

external link
9.

Koebernick H et al. (2002) Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium.

external link
10.

Roger T et al. () MIF regulates innate immune responses through modulation of Toll-like receptor 4.

external link
11.

Donn RP et. al. (2001) A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis.

external link
12.

Kleemann R et al. (2000) Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1.

external link
13.

Weiser WY et al. (1989) Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor.

external link
14.

Esumi N et al. (1998) Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF.

external link
15.

Rossi AG et al. (1998) Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma.

external link
16.

Budarf M et al. (1997) Localization of the human gene for macrophage migration inhibitory factor (MIF) to chromosome 22q11.2.

external link
17.

None (1996) MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid-induced regulator of the immune response.

external link
18.

Bernhagen J et al. (1993) MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia.

external link
19.

Paralkar V et al. (1994) Cloning the human gene for macrophage migration inhibitory factor (MIF).

external link
20.

Bozza M et al. (1995) Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes.

external link
21.

Kozak CA et al. (1995) Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.

external link
22.

Bloom BR et al. (1966) Mechanism of a reaction in vitro associated with delayed-type hypersensitivity.

external link
23.

None (1966) Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.

external link
Update: 14. August 2020
Copyright © 2005-2020 Zentrum für Nephrologie und Stoffwechsel, Dr. Mato Nagel
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Deutschland, Tel.: +49-3576-287922, Fax: +49-3576-287944
Seitenüberblick | Webmail | Haftungsausschluss | Datenschutz