Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel

Macrophagen-Migrations-Hemmungsfaktor

Das MIF-Gen kodiert ein Zytokin, welches für die Regulation von Immunreaktion und Inflammation verantwortlich ist. Genetische Varianten beeinflussen die Neigung zu juveniler Arthritis.

Gentests:

Klinisch Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Forschung Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Systemische idiopathische juvenile Arthritis
IL6
LACC1
MIF

Referenzen:

1.

Weiser WY et al. (1989) Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor.

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2.

None (1966) Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.

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3.

Bloom BR et al. (1966) Mechanism of a reaction in vitro associated with delayed-type hypersensitivity.

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4.

Kozak CA et al. (1995) Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.

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5.

Bozza M et al. (1995) Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes.

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6.

Paralkar V et al. (1994) Cloning the human gene for macrophage migration inhibitory factor (MIF).

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7.

Bernhagen J et al. (1993) MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia.

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8.

None (1996) MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid-induced regulator of the immune response.

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9.

Budarf M et al. (1997) Localization of the human gene for macrophage migration inhibitory factor (MIF) to chromosome 22q11.2.

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10.

Rossi AG et al. (1998) Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma.

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11.

Esumi N et al. (1998) Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF.

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12.

Pastrana DV et al. (1998) Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor.

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13.

Kleemann R et al. (2000) Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1.

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14.

Donn RP et. al. (2001) A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis.

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15.

Roger T et al. () MIF regulates innate immune responses through modulation of Toll-like receptor 4.

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16.

Koebernick H et al. (2002) Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium.

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17.

Donn R et. al. (2002) Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis.

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18.

De Benedetti F et. al. (2003) Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis.

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19.

Amin MA et al. (2003) Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase.

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20.

Wang B et al. (2006) Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses.

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21.

Bernhagen J et al. (2007) MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment.

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22.

Arjona A et al. (2007) Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion.

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23.

Miller EJ et al. (2008) Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.

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Update: 8. Mai 2019