Stimulator der Inteferon Gene
Das TMEM173-Gen kodiert ein transmembranöses Protein welches in die Regulation der angeborenen Immunantwort eingebunden ist und die Interferon-Produktion aktiviert. Mutationen führen zur autosomal dominanten Erkrankung STING-assoziierte Vaskulopathie mit Beginn in der Kindheit.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Sun L et al. (2013) Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
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2. |
Haag SM et al. (2018) Targeting STING with covalent small-molecule inhibitors.
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3. |
Dou Z et al. (2017) Cytoplasmic chromatin triggers inflammation in senescence and cancer.
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4. |
Harding SM et al. (2017) Mitotic progression following DNA damage enables pattern recognition within micronuclei.
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5. |
Lau L et al. (2015) DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway.
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6. |
Bridgeman A et al. (2015) Viruses transfer the antiviral second messenger cGAMP between cells.
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7. |
Gentili M et al. (2015) Transmission of innate immune signaling by packaging of cGAMP in viral particles.
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8. |
West AP et al. (2015) Mitochondrial DNA stress primes the antiviral innate immune response.
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9. |
Jeremiah N et. al. (2014) Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations.
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10. |
Zhu Q et al. (2014) Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation.
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11. |
Liu Y et. al. (2014) Activated STING in a vascular and pulmonary syndrome.
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12. |
Zhang L et al. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.
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13. |
You F et al. (2013) ELF4 is critical for induction of type I interferon and the host antiviral response.
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14. |
Ablasser A et al. (2013) Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
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15. |
Chen H et al. (2011) Activation of STAT6 by STING is critical for antiviral innate immunity.
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16. |
Burdette DL et al. (2011) STING is a direct innate immune sensor of cyclic di-GMP.
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17. |
Ishikawa H et al. (2009) STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.
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18. |
Sun W et al. (2009) ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization.
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19. |
Li Y et al. (2009) ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.
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20. |
Zhong B et al. (2009) The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.
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21. |
Ishikawa H et al. (2008) STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
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22. |
Jin L et al. (2008) MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals.
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23. |
Liu S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
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24. |
Wu J et al. (2013) Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
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Update: 14. August 2020