1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase gamma-2

Argeson AC et al. (1995) Phospholipase C gamma-2 (Plcg2) and phospholipase C gamma-1 (Plcg1) map to distinct regions in the human and mouse genomes.

Hernandez D et al. (1994) Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse.

Kang JS et al. (1996) Cloning and functional analysis of the hematopoietic cell-specific phospholipase C(gamma)2 promoter.

Patterson RL et al. (2002) Phospholipase C-gamma is required for agonist-induced Ca2+ entry.

Yu P et al. (2005) Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry.

Mao D et al. (2006) PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

Everett KL et al. (2009) Characterization of phospholipase C gamma enzymes with gain-of-function mutations.

Ombrello MJ et. al. (2012) Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.

Zhou Q et al. (2012) A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency.