Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Tumornekrose-Faktor

Das TNF-Gen kodiert ein proinflammatorisches Zytokin. Varianten dieses Gens werden mit autosomal dominantem Vererbungsmuster mit einer Neigung zu Asthma und Migräne in Zusammenhang gebracht. Weiterhin scheint eine Assoziation mit vaskulärer Demenz und eine Anfäligkeit für Malaria und septischem Schock zu bestehen.

Diagnostik:

Clinic Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5
Probentyp genomic DNA
Research Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25
Probentyp genomic DNA
Clinic Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25
Probentyp genomic DNA

Krankheiten:

Vaskuläre Demenz
TNF
Malaria
TNF
Migräne
TNF
Septischer Schock
TNF

Referenzen:

1.

Szalai C et. al. (2002) Association of polymorphisms and allelic combinations in the tumour necrosis factor-alpha-complement MHC region with coronary artery disease.

[^]
2.

Buranawuti K et. al. (2007) Variants in mannose-binding lectin and tumour necrosis factor alpha affect survival in cystic fibrosis.

[^]
3.

Wilson AG et. al. (1992) Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product.

[^]
4.

Barnes PF et. al. (1990) Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis.

[^]
5.

None (1985) Tumor necrosis factor (TNF).

[^]
6.

Brenner DA et. al. (1989) Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha.

[^]
7.

Carroll MC et. al. (1987) Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.

[^]
8.

Nedwin GE et. al. (1985) Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization.

[^]
9.

Aggarwal BB et. al. () Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon.

[^]
10.

Müller U et. al. () Tumour necrosis factor and lymphotoxin genes map close to H-2D in the mouse major histocompatibility complex.

[^]
11.

Ragoussis J et. al. (1988) Localization of the genes for tumor necrosis factor and lymphotoxin between the HLA class I and III regions by field inversion gel electrophoresis.

[^]
12.

Spies T et. al. (1986) Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

[^]
13.

Inoko H et. al. (1987) Linkage of TNF genes to the HLA-B locus.

[^]
14.

Broudy VC et. al. (1986) Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor.

[^]
15.

Nedospasov SA et. al. (1986) The genes for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) are tandemly arranged on chromosome 17 of the mouse.

[^]
16.

Davis JM et. al. (1987) Structure of human tumor necrosis factor alpha derived from recombinant DNA.

[^]
17.

Beutler B et. al. (1986) Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance.

[^]
18.

Wang AM et. al. (1985) Molecular cloning of the complementary DNA for human tumor necrosis factor.

[^]
19.

Shirai T et. al. () Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor.

[^]
20.

Pennica D et. al. () Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.

[^]
21.

Flynn JL et. al. (1995) Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice.

[^]
22.

Galbraith GM et. al. (1995) Tumor necrosis factor alpha (TNF-alpha) gene polymorphism in alopecia areata.

[^]
23.

Cabrera M et. al. (1995) Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis.

[^]
24.

Norman RA et. al. (1995) Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians.

[^]
25.

D'Alfonso S et. al. (1994) A polymorphic variation in a putative regulation box of the TNFA promoter region.

[^]
26.

McGuire W et. al. (1994) Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.

[^]
27.

Cox A et. al. (1994) Comparative analysis of the genetic associations of HLA-DR3 and tumour necrosis factor alpha with human IDDM.

[^]
28.

Van Ostade X et. al. (1993) Human TNF mutants with selective activity on the p55 receptor.

[^]
29.

Spielman RS et. al. (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

[^]
30.

Obeid LM et. al. (1993) Programmed cell death induced by ceramide.

[^]
31.

Bruce AJ et. al. (1996) Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors.

[^]
32.

Mulcahy B et. al. (1996) Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis.

[^]
33.

Nadel S et. al. (1996) Variation in the tumor necrosis factor-alpha gene promoter region may be associated with death from meningococcal disease.

[^]
34.

van Hensbroek MB et. al. (1996) The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria.

[^]
35.

Black RA et. al. (1997) A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells.

[^]
36.

Conway DJ et. al. (1997) Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-alpha) gene promoter and with elevated TNF-alpha levels in tear fluid.

[^]
37.

Wilson AG et. al. (1997) Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation.

[^]
38.

Moffatt MF et. al. (1997) Tumour necrosis factor haplotypes and asthma.

[^]
39.

Marino MW et. al. (1997) Characterization of tumor necrosis factor-deficient mice.

[^]
40.

Roy S et. al. (1997) Tumor necrosis factor promoter polymorphism and susceptibility to lepromatous leprosy.

[^]
41.

Uysal KT et. al. (1997) Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.

[^]
42.

Herrmann SM et. al. (1998) Polymorphisms of the tumour necrosis factor-alpha gene, coronary heart disease and obesity.

[^]
43.

Ma JJ et. al. (1998) Genetic contribution of the tumor necrosis factor region in Guillain-Barré syndrome.

[^]
44.

Zinman B et. al. (1999) Circulating tumor necrosis factor-alpha concentrations in a native Canadian population with high rates of type 2 diabetes mellitus.

[^]
45.

Bonifati C et. al. (1999) Cytokines in psoriasis.

[^]
46.

Knight JC et. al. (1999) A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria.

[^]
47.

Skoog T et. al. (1999) A common functional polymorphism (C-->A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha.

[^]
48.

Ruuls SR et. al. (1999) Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and animal models.

[^]
49.

None () The immunogenetics of resistance to malaria.

[^]
50.

Franchimont D et. al. (1999) Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor.

[^]
51.

Mira JP et. al. (1999) Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study.

[^]
52.

Rasmussen SK et. al. (2000) The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians.

[^]
53.

Obayashi H et. al. (2000) Tumor necrosis factor microsatellite polymorphism influences the development of insulin dependency in adult-onset diabetes patients with the DRB1*1502-DQB1*0601 allele and anti-glutamic acid decarboxylase antibodies.

[^]
54.

Winchester EC et. al. (2000) Association of the TNF-alpha-308 (G-->A) polymorphism with self-reported history of childhood asthma.

[^]
55.

Ota N et. al. (2000) Linkage of human tumor necrosis factor-alpha to human osteoporosis by sib pair analysis.

[^]
56.

Koss K et. al. (2000) Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies.

[^]
57.

Moraes MO et. al. (2001) Tumor necrosis factor-alpha promoter polymorphism TNF2 is associated with a stronger delayed-type hypersensitivity reaction in the skin of borderline tuberculoid leprosy patients.

[^]
58.

McCusker SM et. al. (2001) Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: a case-control study.

[^]
59.

Rosmond R et. al. (2001) G-308A polymorphism of the tumor necrosis factor alpha gene promoter and salivary cortisol secretion.

[^]
60.

Escobar-Morreale HF et. al. (2001) TNF-alpha and hyperandrogenism: a clinical, biochemical, and molecular genetic study.

[^]
61.

Quasney MW et. al. (2001) Increased frequency of the tumor necrosis factor-alpha-308 A allele in adults with human immunodeficiency virus dementia.

[^]
62.

Keane J et. al. (2001) Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.

[^]
63.

Witte JS et. al. (2002) Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma.

[^]
64.

Beattie EC et. al. (2002) Control of synaptic strength by glial TNFalpha.

[^]
65.

Roach DR et. al. (2002) TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection.

[^]
66.

Gorman JD et. al. (2002) Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha.

[^]
67.

van Heel DA et. al. (2002) Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors.

[^]
68.

de Groof F et. al. (2002) Acute stress response in children with meningococcal sepsis: important differences in the growth hormone/insulin-like growth factor I axis between nonsurvivors and survivors.

[^]
69.

Janssen R et. al. (2002) Divergent role for TNF-alpha in IFN-gamma-induced killing of Toxoplasma gondii and Salmonella typhimurium contributes to selective susceptibility of patients with partial IFN-gamma receptor 1 deficiency.

[^]
70.

Krikovszky D et. al. (2002) Association between G-308A polymorphism of the tumor necrosis factor-alpha gene and 24-hour ambulatory blood pressure values in type 1 diabetic adolescents.

[^]
71.

García-Ruiz C et. al. (2003) Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice.

[^]
72.

Flori L et. al. (2003) Linkage of mild malaria to the major histocompatibility complex in families living in Burkina Faso.

[^]
73.

Takahashi JL et. al. (2003) Interleukin-1beta promotes oligodendrocyte death through glutamate excitotoxicity.

[^]
74.

Balding J et. al. (2003) Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity.

[^]
75.

Shbaklo H et. al. (2003) No association between the -1031 polymorphism in the TNF-alpha promoter region and type 1 diabetes.

[^]
76.

Li H et. al. (2003) A combination of human leukocyte antigen DQB1*02 and the tumor necrosis factor alpha promoter G308A polymorphism predisposes to an insulin-deficient phenotype in patients with type 2 diabetes.

[^]
77.

Kim YJ et. al. (2003) Association of TNF-alpha promoter polymorphisms with the clearance of hepatitis B virus infection.

[^]
78.

Steed PM et. al. (2003) Inactivation of TNF signaling by rationally designed dominant-negative TNF variants.

[^]
79.

Leonardi CL et. al. (2003) Etanercept as monotherapy in patients with psoriasis.

[^]
80.

Shin HD et. al. (2004) Association of tumor necrosis factor polymorphisms with asthma and serum total IgE.

[^]
81.

Diwan A et. al. (2004) Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes.

[^]
82.

Rainero I et. al. (2004) Association between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine.

[^]
83.

Bouwmeester T et. al. (2004) A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.

[^]
84.

Boyman O et. al. (2004) Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha.

[^]
85.

Allcock RJ et. al. (2004) High-Density SNP genotyping defines 17 distinct haplotypes of the TNF block in the Caucasian population: implications for haplotype tagging.

[^]
86.

Funayama T et. al. (2004) Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma.

[^]
87.

Kamata H et. al. (2005) Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases.

[^]
88.

Vielhauer V et. al. (2005) Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis.

[^]
89.

Balosso S et. al. (2005) Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors.

[^]
90.

Kim JY et. al. (2005) Identification of regulatory polymorphisms in the TNF-TNF receptor superfamily.

[^]
91.

Laws SM et. al. (2005) TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels.

[^]
92.

Fowler EV et. al. (2005) TNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease.

[^]
93.

Stein CM et. al. (2005) Evidence for a major gene influence on tumor necrosis factor-alpha expression in tuberculosis: path and segregation analysis.

[^]
94.

Murray RZ et. al. (2005) A role for the phagosome in cytokine secretion.

[^]
95.

Lee YH et. al. (2006) Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility.

[^]
96.

Stellwagen D et. al. (2006) Synaptic scaling mediated by glial TNF-alpha.

[^]
97.

El-Shabrawi Y et. al. (2006) Polymorphisms within the tumor necrosis factor-alpha promoter region in patients with HLA-B27-associated uveitis: association with susceptibility and clinical manifestations.

[^]
98.

Aoki T et. al. (2006) An association between asthma and TNF-308G/A polymorphism: meta-analysis.

[^]
99.

Ramos EM et. al. (2006) Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease.

[^]
100.

Hase H et. al. (2006) TNFalpha mediates the skeletal effects of thyroid-stimulating hormone.

[^]
101.

Kawane K et. al. (2006) Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.

[^]
102.

Nadkarni S et. al. (2007) Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta.

[^]
103.

Soller JT et. al. (2007) Comparison of the human and canine cytokines IL-1(alpha/beta) and TNF-alpha to orthologous other mammalians.

[^]
104.

Lieu ZZ et. al. (2008) A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo.

[^]
105.

Li X et. al. (2008) A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease.

[^]
106.

Guo R et. al. (2008) Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.

[^]
107.

Tay S et. al. (2010) Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing.

[^]
108.

Feldmann M et. al. (2010) Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?

[^]
109.

Huang MT et. al. (2010) Deletion of ripA alleviates suppression of the inflammasome and MAPK by Francisella tularensis.

[^]
110.

Günther C et. al. (2011) Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

[^]
111.

Braumüller H et. al. (2013) T-helper-1-cell cytokines drive cancer into senescence.

[^]
112.

Li Z et. al. (2014) The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL.

[^]
Update: 26. September 2018

 

Die Seite verwendet Cookies, um Ihnen den bestmöglichen Service zu gewährleisten. Bitte bestätigen Sie uns kurz per Klick, dass Sie mit der Nutzung von Cookies einverstanden sind: