Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Interleukin-4

Das IL4-Gen kodiert Interleukin-4 ein wichtiges Zytokin, welches von aktivierten T-Lymphozyten produziert wird. Damit besitzt es eine wichtige Regulatorfunktion bei Immunprozessen.

Diagnostik:

Clinic Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5
Probentyp genomic DNA
Research Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25
Probentyp genomic DNA
Clinic Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25
Probentyp genomic DNA

Krankheiten:

Referenzen:

1.

Fields PE et al. (2002) Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation.

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2.

Smirnov DV et. al. (1995) Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization.

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3.

Loots GG et. al. (2000) Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.

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4.

Lacy DA et. al. (2000) Faithful expression of the human 5q31 cytokine cluster in transgenic mice.

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5.

Kelly-Welch AE et. al. (2003) Interleukin-4 and interleukin-13 signaling connections maps.

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6.

LaPorte SL et. al. (2008) Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.

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7.

Wu D et. al. (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.

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8.

Bosurgi L et. al. (2017) Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.

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9.

Arai N et. al. (1989) Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.

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10.

Takahashi M et. al. (1989) Chromosomal mapping of the mouse IL-4 and human IL-5 genes.

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11.

Le Beau MM et. al. (1989) Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q).

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12.

Yokota T et. al. (1986) Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

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13.

Eder A et. al. (1988) The 5' region of the human interleukin 4 gene: structure and potential regulatory elements.

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14.

Sutherland GR et. al. (1988) Interleukin 4 is at 5q31 and interleukin 6 is at 7p15.

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15.

Leung DY et. al. (1988) Clinical and immunologic aspects of the hyperimmunoglobulin E syndrome.

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16.

Lewis DB et. al. (1993) Osteoporosis induced in mice by overproduction of interleukin 4.

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17.

Saltman DL et. al. (1993) A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization.

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18.

Le Beau MM et. al. (1993) Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases.

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19.

Kotanides H et. al. (1996) Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene.

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20.

Kawashima T et. al. (1998) Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.

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21.

Dickensheets HL et. al. (1999) Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.

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22.

Hunt PJ et. al. (2000) Cytokine gene polymorphisms in autoimmune thyroid disease.

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23.

Carvalho LH et. al. (2002) IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

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24.

Inoue T et. al. (2002) Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis.

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25.

Ozaki K et. al. (2002) A critical role for IL-21 in regulating immunoglobulin production.

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26.

Messi M et al. (2003) Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes.

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27.

Ghoreschi K et. al. (2003) Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease.

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28.

Horsley V et. al. (2003) IL-4 acts as a myoblast recruitment factor during mammalian muscle growth.

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29.

Zavros Y et. al. (2003) Treatment of Helicobacter gastritis with IL-4 requires somatostatin.

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30.

Zee RY et. al. (2004) Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis.

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31.

Spilianakis CG et al. (2005) Interchromosomal associations between alternatively expressed loci.

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32.

Nguyen KD et. al. (2011) Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.

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33.

Vijayanand P et. al. (2012) Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V.

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34.

Harada Y et. al. (2012) The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells.

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35.

Reese TA et. al. (2014) Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter.

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36.

Osborne LC et. al. (2014) Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation.

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37.

Minutti CM et. al. (2017) Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver.

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Update: 26. September 2018

 

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