Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Interleukin-13

Das IL13-Gen kodiert Interleukin-13, ein wichtiges Zytokin, welches von T-Helfer-Zellen 2 sezerniert wird. Damit besitzt es eine wichtige Regulatorfunktion bei Immunprozessen, so bei der Neigung zu Asthma und allergischer Rhinitis.

Diagnostik:

Clinic Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5
Probentyp genomic DNA
Research Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25
Probentyp genomic DNA
Clinic Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25
Probentyp genomic DNA

Krankheiten:

Neigung zu allergischer Rhinitis
IL13
Neigung zu Asthma bronchiale
IL13

Referenzen:

1.

Morgan JG et. al. (1992) The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes.

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2.

Smirnov DV et. al. (1995) Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization.

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3.

Zurawski G et. al. (1994) Interleukin 13 elicits a subset of the activities of its close relative interleukin 4.

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4.

Minty A et. al. (1993) Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses.

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5.

Punnonen J et. al. (1993) Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

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6.

McKenzie AN et. al. (1993) Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function.

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7.

Wills-Karp M et. al. (1998) Interleukin-13: central mediator of allergic asthma.

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8.

Grünig G et. al. (1998) Requirement for IL-13 independently of IL-4 in experimental asthma.

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9.

Zhu Z et. al. (1999) Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.

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10.

Heinzmann A et. al. (2000) Genetic variants of IL-13 signalling and human asthma and atopy.

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11.

Loots GG et. al. (2000) Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.

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12.

Lacy DA et. al. (2000) Faithful expression of the human 5q31 cytokine cluster in transgenic mice.

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13.

Zheng T et. al. (2000) Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema.

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14.

Howard TD et. al. (2001) Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population.

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15.

Howard TD et. al. (2002) Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma.

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16.

Kuperman DA et. al. (2002) Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.

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17.

Lanone S et. al. (2002) Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling.

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18.

Kelly-Welch AE et. al. (2003) Interleukin-4 and interleukin-13 signaling connections maps.

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19.

He JQ et. al. (2003) Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children.

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20.

Blackburn MR et. al. (2003) Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway.

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21.

Wang M et. al. (2003) A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis.

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22.

Zhu Z et. al. (2004) Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.

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23.

Chen W et. al. (2004) Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants.

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24.

Hiromatsu Y et. al. (2005) Interleukin-13 gene polymorphisms confer the susceptibility of Japanese populations to Graves' disease.

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25.

Chen Q et. al. (2005) IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling.

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26.

Vladich FD et. al. (2005) IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation.

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27.

Kouriba B et. al. (2005) Analysis of the 5q31-q33 locus shows an association between IL13-1055C/T IL-13-591A/G polymorphisms and Schistosoma haematobium infections.

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28.

Fichtner-Feigl S et. al. (2006) IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis.

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29.

LaPorte SL et. al. (2008) Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.

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30.

Neill DR et. al. (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.

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31.

Wu D et. al. (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.

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32.

Nussbaum JC et. al. (2013) Type 2 innate lymphoid cells control eosinophil homeostasis.

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33.

Bosurgi L et. al. (2017) Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.

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Update: 26. September 2018

 

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