Interleukin-13
Das IL13-Gen kodiert Interleukin-13, ein wichtiges Zytokin, welches von T-Helfer-Zellen 2 sezerniert wird. Damit besitzt es eine wichtige Regulatorfunktion bei Immunprozessen, so bei der Neigung zu Asthma und allergischer Rhinitis.
Gentests:
| Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
| Bearbeitungszeit |
5 Tage |
| Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
| 1. |
Morgan JG et. al. (1992) The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes.
[^]
|
| 2. |
Smirnov DV et. al. (1995) Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization.
[^]
|
| 3. |
Zurawski G et. al. (1994) Interleukin 13 elicits a subset of the activities of its close relative interleukin 4.
[^]
|
| 4. |
Minty A et. al. (1993) Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses.
[^]
|
| 5. |
Punnonen J et. al. (1993) Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.
[^]
|
| 6. |
McKenzie AN et. al. (1993) Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function.
[^]
|
| 7. |
Wills-Karp M et. al. (1998) Interleukin-13: central mediator of allergic asthma.
[^]
|
| 8. |
Grünig G et. al. (1998) Requirement for IL-13 independently of IL-4 in experimental asthma.
[^]
|
| 9. |
Zhu Z et. al. (1999) Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.
[^]
|
| 10. |
Heinzmann A et. al. (2000) Genetic variants of IL-13 signalling and human asthma and atopy.
[^]
|
| 11. |
Loots GG et. al. (2000) Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.
[^]
|
| 12. |
Lacy DA et. al. (2000) Faithful expression of the human 5q31 cytokine cluster in transgenic mice.
[^]
|
| 13. |
Zheng T et. al. (2000) Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema.
[^]
|
| 14. |
Howard TD et. al. (2001) Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population.
[^]
|
| 15. |
Howard TD et. al. (2002) Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma.
[^]
|
| 16. |
Kuperman DA et. al. (2002) Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.
[^]
|
| 17. |
Lanone S et. al. (2002) Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling.
[^]
|
| 18. |
Kelly-Welch AE et. al. (2003) Interleukin-4 and interleukin-13 signaling connections maps.
[^]
|
| 19. |
He JQ et. al. (2003) Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children.
[^]
|
| 20. |
Blackburn MR et. al. (2003) Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway.
[^]
|
| 21. |
Wang M et. al. (2003) A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis.
[^]
|
| 22. |
Zhu Z et. al. (2004) Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.
[^]
|
| 23. |
Chen W et. al. (2004) Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants.
[^]
|
| 24. |
Hiromatsu Y et. al. (2005) Interleukin-13 gene polymorphisms confer the susceptibility of Japanese populations to Graves' disease.
[^]
|
| 25. |
Chen Q et. al. (2005) IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling.
[^]
|
| 26. |
Vladich FD et. al. (2005) IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation.
[^]
|
| 27. |
Kouriba B et. al. (2005) Analysis of the 5q31-q33 locus shows an association between IL13-1055C/T IL-13-591A/G polymorphisms and Schistosoma haematobium infections.
[^]
|
| 28. |
Fichtner-Feigl S et. al. (2006) IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis.
[^]
|
| 29. |
LaPorte SL et. al. (2008) Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.
[^]
|
| 30. |
Neill DR et. al. (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
[^]
|
| 31. |
Wu D et. al. (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
[^]
|
| 32. |
Nussbaum JC et. al. (2013) Type 2 innate lymphoid cells control eosinophil homeostasis.
[^]
|
| 33. |
Bosurgi L et. al. (2017) Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.
[^]
|
Update: 26. September 2018
