Zytoplasmatische Isozitratdehydrogenase [NADP]

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Xu X et al. (2004) Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity.

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Zhao S et al. (2009) Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.

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Lu C et al. (2012) IDH mutation impairs histone demethylation and results in a block to cell differentiation.

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Losman JA et al. (2013) (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.

Rohle D et al. (2013) An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

Saha SK et al. (2014) Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.

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None (1972) Genetics of human-mouse somatic cell hybrids: linkage of human genes for isocitrate dehydrogenase and malate dehydrogenase.

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