Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Natriuretisches Peptid Typ C

Das NPPC kodiert ein Peptidhormon welches in der Regulation des Wasser und Natriumhaushaltes eingebunden ist.

Diagnostik:

Clinic Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5
Probentyp genomic DNA
Research Untersuchungsmethoden Multiplex ligationsabhängige Amplifikation
Bearbeitungszeit 25
Probentyp genomic DNA
Research Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25
Probentyp genomic DNA
Clinic Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25
Probentyp genomic DNA

Krankheiten:

Referenzen:

1.

Yasoda A et. al. (2004) Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.

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2.

Sudoh T et. al. (1990) C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain.

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3.

Minamino N et. al. (1990) N-terminally extended form of C-type natriuretic peptide (CNP-53) identified in porcine brain.

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4.

Ogawa Y et. al. (1994) Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC).

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5.

Suda M et. al. (1998) Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide.

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6.

Yasoda A et. al. (1998) Natriuretic peptide regulation of endochondral ossification. Evidence for possible roles of the C-type natriuretic peptide/guanylyl cyclase-B pathway.

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7.

Chusho H et. al. (2001) Dwarfism and early death in mice lacking C-type natriuretic peptide.

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8.

Zhang M et. al. (2010) Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes.

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Update: 31. März 2018