Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Plasminogen

Das PLG-Gen kodiert Plasminogen ein Zymogen, welches wenn aktiviert die Auflösung von Fibrin-Thromben bewirkt. Mutationen führen zu autosomal rezessivem Plasminogen-Mangel und Conjunctivitis lignosa. Das bei der Aktivierung abgetrennte Spaltprodukt besitzt eine angiostatische Wirkung. Erkrankungen, die diesen Teil des Proteins betreffen, sind bisher noch nicht bekannt.

Diagnostik:

Clinic Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5
Probentyp genomic DNA
Research Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25
Probentyp genomic DNA
Clinic Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25
Probentyp genomic DNA

Krankheiten:

Dysplasminogenemie
PLG
Hypoplasminogenemie
PLG
Hämolytisch Urämisches Syndrom
ADAMTS13
C3
C4BPA
C4BPB
CD46
CFB
CFH
CFHR1
CFHR2
CFHR3
CFHR4
CFHR5
CFI
CLU
DGKE
Methylmalonazidurie
Methylmalonazidurie Typ mut
MUT
Methylmalonazidurie mit Homozysteinurie cblC
MMACHC
Methylmalonazidurie mit Homozysteinurie cblD
MMADHC
PIGA
PLG
THBD

Referenzen:

1.

O'Reilly MS et. al. (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.

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2.

Kunert A et. al. (2007) Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein.

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3.

Soria J et al. (1983) Plasminogen Paris I: congenital abnormal plasminogen and its incidence in thrombosis.

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4.

McLean JW et al. () cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.

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5.

None (1979) Genetic polymorphism of human plasminogen.

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6.

Aoki N et. al. (1978) Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis.

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7.

Kikuchi S et. al. () Plasminogen with type-I mutation is polymorphic in the Japanese population.

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8.

Shigekiyo T et. al. (1992) Type I congenital plasminogen deficiency is not a risk factor for thrombosis.

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9.

Ichinose A et. al. (1991) Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis.

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10.

Degen SJ et. al. (1990) Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17.

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11.

None (1990) Ligneous conjunctivitis: an ophthalmic disease with potentially fatal tracheobronchial obstruction. Laryngeal and tracheobronchial features.

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12.

Petersen TE et. al. (1990) Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system.

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13.

Murray JC et. al. (1987) Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27.

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14.

Scharrer IM et. al. (1986) Investigation of a congenital abnormal plasminogen, Frankfurt I, and its relationship to thrombosis.

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15.

Wu HL et. al. (1987) Preparation and purification of microplasmin.

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16.

Wu HL et. al. (1987) Structure and formation of microplasmin.

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17.

Forsgren M et. al. (1987) Molecular cloning and characterization of a full-length cDNA clone for human plasminogen.

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18.

Dolan G et. al. (1988) Thrombovascular disease and familial plasminogen deficiency: a report of three kindreds.

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19.

Hach-Wunderle V et. al. (1988) Congenital deficiency of plasminogen and its relationship to venous thrombosis.

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20.

Bateman JB et. al. () Ligneous conjunctivitis: an autosomal recessive disorder.

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21.

Mannucci PM et. al. (1986) Congenital plasminogen deficiency associated with venous thromboembolism: therapeutic trial with stanozolol.

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22.

Miyata T et. al. (1982) Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.

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23.

Wohl RC et. al. (1982) Human plasminogen variant Chicago III.

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24.

Miyata T et. al. (1984) Plasminogens Tochigi II and Nagoya: two additional molecular defects with Ala-600----Thr replacement found in plasmin light chain variants.

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25.

Sakata Y et. al. (1980) Molecular abnormality of plasminogen.

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26.

Eiberg H et. al. (1984) Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system.

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27.

Bissbort S et. al. (1983) Genetic linkage relations of the human plasminogen gene.

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28.

Nakamura S et. al. (1982) Genetic polymorphism of human plasminogen in the Japanese population: new plasminogen variants and relationship between plasminogen phenotypes and their biological activities.

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29.

Ikemoto S et. al. (1982) Genetic polymorphism of human plasminogen in a Japanese population.

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30.

Kazama M et. al. () Abnormal plasminogen, a case of recurrent thrombosis.

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31.

Raum D et. al. (1980) Genetic polymorphism of human plasminogen.

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32.

Magnaghi P et. al. (1995) A recombination event in the closely linked plasminogen and apolipoprotein(a) gene loci.

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33.

Ploplis VA et. al. (1995) Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.

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34.

Bugge TH et. al. (1995) Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

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35.

Rao PH et. al. (1994) Subregional mapping of 8 single copy loci to chromosome 6 by fluorescence in situ hybridization.

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36.

Patrassi GM et. al. (1993) Unusual thrombotic-like retinopathy (Coats' disease) associated with congenital plasminogen deficiency type I.

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37.

Azuma H et. al. (1993) Congenital plasminogen deficiency caused by a Ser572 to Pro mutation.

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38.

Romer J et. al. (1996) Impaired wound healing in mice with a disrupted plasminogen gene.

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39.

Gately S et. al. (1996) Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin.

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40.

Cao Y et. al. (1996) Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells.

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41.

Tait RC et. al. (1996) Isolated familial plasminogen deficiency may not be a risk factor for thrombosis.

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42.

Boyle MD et. al. (1997) Plasminogen activation by invasive human pathogens.

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43.

Kida M et. al. (1997) Characterization of the 5'-flanking regions of plasminogen-related genes A and B.

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44.

Schuster V et. al. (1997) Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.

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45.

Murata M et. al. (1997) Ala601-Thr type dysplasminogenaemia genetically diagnosed in patients with retinochoroidal vascular disorders.

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46.

Drew AF et. al. (1998) Ligneous conjunctivitis in plasminogen-deficient mice.

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47.

Cao Y et. al. (1998) Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases.

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48.

Kao WW et. al. (1998) Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice.

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49.

Iijima H et. al. (1998) Familial dysplasminogenemia with central retinal vein and cilioretinal artery occlusion.

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50.

Schott D et. al. (1998) Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency.

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51.

Higuchi Y et. al. (1998) Plasminogen Kanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R.

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52.

Gebbia JA et. al. (1999) The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.

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53.

Schuster V et. al. (1999) Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis.

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54.

Fischer MB et. al. (2000) Binding of disease-associated prion protein to plasminogen.

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55.

Drixler TA et. al. (2001) Angiostatin inhibits pathological but not physiological retinal angiogenesis.

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56.

Swaisgood CM et. al. (2002) In vivo regulation of plasminogen function by plasma carboxypeptidase B.

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57.

Schuster V et. al. () Ligneous conjunctivitis.

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58.

Lund LR et. al. (2006) Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.

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59.

Tefs K et. al. (2006) Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients.

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60.

Nguyen TM et. al. (2007) Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells.

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61.

Gong Y et. al. (2008) Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice.

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Update: 26. September 2018

 

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