Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Fibroblastenwachstumsfaktor 10

Das FGF10-Gen kodiert einen Fibroblastenwachstumsfaktor der bei der Entwicklung von Gehirns, Lunge und Extremitäten sowie bei der Wundheilung beteiligt ist. Mutationen führen zu autosomal dominanten Erkrankungen Tränen- und Speicheldrüsenaplasie und Lakrimo-aurikulo-dento-digitales Syndrom.

Gentests:

Klinisch Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Forschung Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Forschung Untersuchungsmethoden Multiplex ligationsabhängige Amplifikation
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Tränen- und Speicheldrüsenaplasie
FGF10
Lakrimo-aurikulo-dento-digitales Syndrom
FGF10

Referenzen:

1.

Rice R et al. (2004) Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate.

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2.

Gros J et al. (2014) Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition.

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3.

Frenz DA et al. (2010) Retinoid signaling in inner ear development: A "Goldilocks" phenomenon.

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4.

Nechiporuk A et al. (2008) FGF-dependent mechanosensory organ patterning in zebrafish.

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5.

Umemori H et al. (2004) FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.

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6.

Sakaue H et al. (2002) Requirement of fibroblast growth factor 10 in development of white adipose tissue.

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7.

Bagai S et al. (2002) Fibroblast growth factor-10 is a mitogen for urothelial cells.

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8.

Kelly RG et al. (2001) The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm.

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9.

Suzuki K et al. (2000) Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene.

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10.

None (1999) Morphogenesis.

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11.

Sekine K et al. (1999) Fgf10 is essential for limb and lung formation.

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12.

Min H et al. (1998) Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.

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13.

Emoto H et al. (1997) Structure and expression of human fibroblast growth factor-10.

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14.

Klar J et al. (2011) Fibroblast growth factor 10 haploinsufficiency causes chronic obstructive pulmonary disease.

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15.

Entesarian M et al. (2007) FGF10 missense mutations in aplasia of lacrimal and salivary glands (ALSG).

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16.

Milunsky JM et al. (2006) LADD syndrome is caused by FGF10 mutations.

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17.

Entesarian M et al. (2005) Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.

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18.

Watanabe Y et al. (2010) Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.

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19.

Rohmann E et al. (2006) Mutations in different components of FGF signaling in LADD syndrome.

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20.

Orphanet article

Orphanet ID 121794 external link
21.

NCBI article

NCBI 2255 external link
22.

OMIM.ORG article

Omim 602115 external link
Update: 14. August 2020
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