Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Thyrotropin-Releasing-Hormon (TRH)

Durch das TRH-Gen wird das Thyrotropin-Releasing-Hormon kodiert. Mutationen führen zur autosomal rezessiven hypothalamischen Hypothyreose.

Diagnostik:

Clinic Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5
Probentyp genomic DNA
Research Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25
Probentyp genomic DNA

Krankheiten:

TRH-Mangel
TRH

Referenzen:

1.

Krashes MJ et. al. (2014) An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.

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2.

Yamada M et. al. (1991) Assignment of human preprothyrotropin-releasing hormone (TRH) gene to chromosome 3.

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3.

Yamada M et. al. (1990) Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone.

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4.

Roller ML et. al. (1995) Localization of the thyrotropin-releasing hormone gene, Trh, on mouse chromosome 6.

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5.

Yamada M et. al. (1999) Assignment of the thyrotropin-releasing hormone gene (TRH) to human chromosome 3q13.3-->q21 by in situ hybridization.

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6.

Gáspár E et. al. (2010) Thyrotropin releasing hormone (TRH): a new player in human hair-growth control.

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