Appetit-regulierendes Hormon
Das GHRL-Gen codiert ein Protein, welches in zwei Peptidhormone gespalten wird, die in der Regulation von Appetit und Energieaufnahme bzw. -bilanzierung beteiligt sind. Mutationen sind mit Adipositas in Zusammenhang gebracht. Die Vererbung folgt einem dominanten Model. Es kann zudem zu synergistischen Reaktionen mit Mutationen in anderen Genen kommen.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Theander-Carrillo C et al. (2006) Ghrelin action in the brain controls adipocyte metabolism.
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2. |
Pagotto U et al. (2003) Testosterone replacement therapy restores normal ghrelin in hypogonadal men.
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3. |
Leonetti F et al. (2003) Different plasma ghrelin levels after laparoscopic gastric bypass and adjustable gastric banding in morbid obese subjects.
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4. |
Farquhar J et al. (2003) Elevated umbilical cord ghrelin concentrations in small for gestational age neonates.
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5. |
Wortley KE et al. (2004) Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference.
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6. |
Leidy HJ et al. (2004) Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women.
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7. |
Steinle NI et al. (2005) Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish.
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8. |
Zhang JV et al. (2005) Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.
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9. |
Wortley KE et al. (2005) Absence of ghrelin protects against early-onset obesity.
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10. |
Doi A et al. (2006) IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.
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11. |
Zigman JM et al. (2005) Mice lacking ghrelin receptors resist the development of diet-induced obesity.
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12. |
Abizaid A et al. (2006) Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.
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13. |
Chartrel N et al. (2007) Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".
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14. |
Kluge M et al. (2007) Ghrelin suppresses secretion of luteinizing hormone in humans.
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15. |
Checchi S et al. (2007) Serum ghrelin as a marker of atrophic body gastritis in patients with parietal cell antibodies.
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16. |
Dixit VD et al. (2007) Ghrelin promotes thymopoiesis during aging.
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17. |
Yang J et al. (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.
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18. |
Feigerlová E et al. (2008) Hyperghrelinemia precedes obesity in Prader-Willi syndrome.
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19. |
Kirchner H et al. (2009) GOAT links dietary lipids with the endocrine control of energy balance.
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20. |
Jerlhag E et al. (2009) Requirement of central ghrelin signaling for alcohol reward.
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21. |
Corbetta S et al. (2003) Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma.
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22. |
Dixit VD et al. (2004) Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells.
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23. |
Andrews ZB et al. (2008) UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
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24. |
Kojima M et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
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25. |
Tschöp M et al. (2000) Ghrelin induces adiposity in rodents.
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26. |
Date Y et al. (2000) Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.
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27. |
Takaya K et al. (2000) Ghrelin strongly stimulates growth hormone release in humans.
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28. |
Date Y et al. (2001) Ghrelin acts in the central nervous system to stimulate gastric acid secretion.
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29. |
Nakazato M et al. (2001) A role for ghrelin in the central regulation of feeding.
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30. |
Kojima M et al. (2001) Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.
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31. |
Ukkola O et al. (2001) Mutations in the preproghrelin/ghrelin gene associated with obesity in humans.
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32. |
Tanaka M et al. (2001) Testis-specific and developmentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse.
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33. |
Cummings DE et al. (2002) Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.
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34. |
Hinney A et al. (2002) Ghrelin gene: identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students.
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35. |
Korbonits M et al. (2002) A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children.
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36. |
DelParigi A et al. (2002) High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome.
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37. |
Haqq AM et al. (2003) Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome.
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38. |
Cowley MA et al. (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.
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39. |
Popovic V et al. (2003) Ghrelin main action on the regulation of growth hormone release is exerted at hypothalamic level.
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40. |
NCBI article
NCBI 51738
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41. |
OMIM.ORG article
Omim 605353
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42. |
Wikipedia Artikel
Wikipedia DE (Ghrelin)
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Update: 14. August 2020