Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Enzym APOBEC-3G

Das vom APOBEC3G-Gen kodierte Enzym gehört in die APOBEC-Familie von Enzymen, welche die mRNA nach der Transkription und vor der Translation verändern indem Basenaustausche vorgenommen werden. Diese Enzyme besitzen eine wichtige Funktion in der Abwehr von Virusinfektionen und im Fettstoffwechsel.

Gentests:

Klinisch Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Forschung Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Störungen der mRNA-Editiertfunktion
APOBEC1
APOBEC2
APOBEC3A
APOBEC3B
APOBEC3C
APOBEC3D
APOBEC3F
APOBEC3G
APOBEC3H
APOBEC4

Referenzen:

1.

Jarmuz A et al. (2002) An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.

external link
2.

Sheehy AM et al. (2002) Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.

external link
3.

Okeoma CM et al. (2010) APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions.

external link
4.

Santoni de Sio FR et al. (2009) APOBEC3G-depleted resting CD4+ T cells remain refractory to HIV1 infection.

external link
5.

Kamata M et al. (2009) Reassessing the role of APOBEC3G in human immunodeficiency virus type 1 infection of quiescent CD4+ T-cells.

external link
6.

Kinoshita SM et al. (2008) NF-IL6 (C/EBPbeta) induces HIV-1 replication by inhibiting cytidine deaminase APOBEC3G.

external link
7.

Chen KM et al. (2008) Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G.

external link
8.

Wang T et al. (2007) 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G.

external link
9.

Okeoma CM et al. (2007) APOBEC3 inhibits mouse mammary tumour virus replication in vivo.

external link
10.

Chiu YL et al. (2005) Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells.

external link
11.

Esnault C et al. (2005) APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses.

external link
12.

Rösler C et al. (2004) Comment on "Inhibition of hepatitis B virus replication by APOBEC3G".

external link
13.

Zhang J et al. (2004) Rapid evolution of primate antiviral enzyme APOBEC3G.

external link
14.

Xu H et al. (2004) A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.

external link
15.

Turelli P et al. (2004) Inhibition of hepatitis B virus replication by APOBEC3G.

external link
16.

Bogerd HP et al. (2004) A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor.

external link
17.

Schröfelbauer B et al. (2004) A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif).

external link
18.

Yu X et al. (2003) Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.

external link
19.

Marin M et al. (2003) HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation.

external link
20.

Sheehy AM et al. (2003) The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif.

external link
21.

Harris RS et al. (2003) DNA deamination mediates innate immunity to retroviral infection.

external link
22.

Mangeat B et al. (2003) Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.

external link
23.

Zhang H et al. (2003) The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA.

external link
24.

Harris RS et al. (2002) RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.

external link
25.

NCBI article

NCBI 60489 external link
26.

OMIM.ORG article

Omim 607113 external link
27.

Wikipedia Artikel

Wikipedia DE (APOBEC3) external link
Update: 14. August 2020
Copyright © 2005-2020 Zentrum für Nephrologie und Stoffwechsel, Dr. Mato Nagel
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Deutschland, Tel.: +49-3576-287922, Fax: +49-3576-287944
Seitenüberblick | Webmail | Haftungsausschluss | Datenschutz