Serine/Threonine-Proteinkinase Sgk1

Webster MK et al. (1993) Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum.

Waldegger S et al. (1997) Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.

Waldegger S et al. (1998) Genomic organization and chromosomal localization of the human SGK protein kinase gene.

Kobayashi T et al. (1999) Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.

Park J et al. (1999) Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway.

Lang F et al. (2000) Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy.

Mikosz CA et al. (2001) Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1.

Tsai KJ et al. (2002) sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats.

Arteaga MF et al. (2006) An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery.

Arteaga MF et al. (2008) A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons.

Salker MS et al. (2011) Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure.

Wu C et al. (2013) Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.

Kleinewietfeld M et al. (2013) Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.

NCBI article

OMIM.ORG article