Fibroblasten-Wachstumsfaktor-Rezeptor 4
Das FGFR4-Gen kodiert ein FGF-Rezeptor. Eine Bedeutung dieses Rezeptors für die Tumorprogression wird vermutet.
Gentests:
Forschung |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Keegan K et al. (1991) Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.
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2. |
Avraham KB et al. (1994) Mapping of murine fibroblast growth factor receptors refines regions of homology between mouse and human chromosomes.
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3. |
Warrington JA et al. (1992) A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5.
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4. |
Armstrong E et al. (1992) Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter.
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5. |
Vainikka S et al. (1992) Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction.
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6. |
Partanen J et al. (1991) FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.
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7. |
Holtrich U et al. (1991) Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.
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8. |
Kostrzewa M et al. (1998) Genomic structure and complete sequence of the human FGFR4 gene.
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9. |
Jung J et al. (1999) Initiation of mammalian liver development from endoderm by fibroblast growth factors.
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10. |
Bange J et al. (2002) Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele.
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11. |
Taylor JG et al. (2009) Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.
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12. |
NCBI article
NCBI 2264
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13. |
OMIM.ORG article
Omim 134935
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Update: 14. August 2020