Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Fibroblasten-Wachstumsfaktor-Rezeptor 4

Das FGFR4-Gen kodiert ein FGF-Rezeptor. Eine Bedeutung dieses Rezeptors für die Tumorprogression wird vermutet.

Gentests:

Forschung Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Forschung Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Referenzen:

1.

Keegan K et al. (1991) Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.

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2.

Avraham KB et al. (1994) Mapping of murine fibroblast growth factor receptors refines regions of homology between mouse and human chromosomes.

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3.

Warrington JA et al. (1992) A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5.

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4.

Armstrong E et al. (1992) Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter.

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5.

Vainikka S et al. (1992) Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction.

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6.

Partanen J et al. (1991) FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.

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7.

Holtrich U et al. (1991) Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.

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8.

Kostrzewa M et al. (1998) Genomic structure and complete sequence of the human FGFR4 gene.

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9.

Jung J et al. (1999) Initiation of mammalian liver development from endoderm by fibroblast growth factors.

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10.

Bange J et al. (2002) Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele.

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11.

Taylor JG et al. (2009) Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.

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12.

NCBI article

NCBI 2264 external link
13.

OMIM.ORG article

Omim 134935 external link
Update: 14. August 2020
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