Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Angiopoietin-related Protein 4

Das ANGPTL4-Gen kodiert ein glycosiliertes Hormon welches in der Regulation der Glukose-Homöostase, des Lipidstoffwechsels und der Insulin-Sensitivität beteiligt ist. Mutationen werden im Zusammenhang mit familiärer Hypertrigylceridämie gesehen.

Gentests:

Forschung Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Forschung Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Veranlagung für hohe Triglyceridwerte
ANGPTL4

Referenzen:

1.

Cefalù AB et al. () Identification of a novel LMF1 nonsense mutation responsible for severe hypertriglyceridemia by targeted next-generation sequencing.

external link
2.

Zheng J et al. (2012) Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development.

external link
3.

Romeo S et al. (2009) Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.

external link
4.

Dewey FE et al. (2016) Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.

external link
5.

Kersten S et al. (2000) Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene.

external link
6.

Yoon JC et al. (2000) Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.

external link
7.

Bäckhed F et al. (2004) The gut microbiota as an environmental factor that regulates fat storage.

external link
8.

Minn AJ et al. (2005) Genes that mediate breast cancer metastasis to lung.

external link
9.

Sukonina V et al. (2006) Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue.

external link
10.

Galaup A et al. (2006) Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness.

external link
11.

Romeo S et al. (2007) Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.

external link
12.

Padua D et al. (2008) TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4.

external link
13.

Talmud PJ et al. (2008) ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.

external link
14.

Yin W et al. (2009) Genetic variation in ANGPTL4 provides insights into protein processing and function.

external link
15.

NCBI article

NCBI 51129 external link
16.

OMIM.ORG article

Omim 605910 external link
Update: 14. August 2020
Copyright © 2005-2020 Zentrum für Nephrologie und Stoffwechsel, Dr. Mato Nagel
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Deutschland, Tel.: +49-3576-287922, Fax: +49-3576-287944
Seitenüberblick | Webmail | Haftungsausschluss | Datenschutz