Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Multidrug-Resistenz-Protein 1

Das ABCB1-Gen kodiert ein Transportprotein, welches am Metabolismus verschiedener Medikamente beteiligt ist. Verschiedene Variationen werden im Zusammenhang mit einer inflammatorischen Darmerkrankung gesehen.

Gentests:

Forschung Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Forschung Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Veranlagung für entzündliche Darmerkrankungen 13
ABCB1

Referenzen:

1.

Siddiqui A et al. (2003) Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.

external link
2.

Gros P et al. (1986) Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins.

external link
3.

Baldini N et al. (1995) Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome.

external link
4.

Schinkel AH et al. (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.

external link
5.

van Helvoort A et al. (1996) MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.

external link
6.

Mickley LA et al. (1997) Gene rearrangement: a novel mechanism for MDR-1 gene activation.

external link
7.

Kim RB et al. (1998) The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

external link
8.

Randolph GJ et al. (1998) A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels.

external link
9.

Lankas GR et al. () Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice.

external link
10.

Smit JW et al. (1999) Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure.

external link
11.

Hoffmeyer S et al. (2000) Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.

external link
12.

Synold TW et al. (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux.

external link
13.

Schaeffeler E et al. (2001) Frequency of C3435T polymorphism of MDR1 gene in African people.

external link
14.

Mealey KL et al. (2001) Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.

external link
15.

Brant SR et al. (2003) MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.

external link
16.

Tang K et al. (2004) Genomic evidence for recent positive selection at the human MDR1 gene locus.

external link
17.

Neff MW et al. (2004) Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage.

external link
18.

Zimprich F et al. (2004) Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy.

external link
19.

Tan NC et al. (2004) Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy.

external link
20.

Tate SK et al. (2005) Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin.

external link
21.

Dong J et al. (2005) Structural basis of energy transduction in the transport cycle of MsbA.

external link
22.

Wang YC et al. (2006) Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines.

external link
23.

Dawson RJ et al. (2006) Structure of a bacterial multidrug ABC transporter.

external link
24.

Kimchi-Sarfaty C et al. (2007) A "silent" polymorphism in the MDR1 gene changes substrate specificity.

external link
25.

Sims-Mourtada J et al. (2007) Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport.

external link
26.

Aller SG et al. (2009) Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.

external link
27.

Bao L et al. (2012) Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298.

external link
28.

Katayama K et al. (2014) Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function.

external link
29.

Pastan I et al. (1987) Multiple-drug resistance in human cancer.

external link
30.

Panwala CM et al. (1998) A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis.

external link
31.

Ho GT et al. (2006) ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach.

external link
32.

de Lannoy IA et al. (1992) The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.

external link
33.

Trezise AE et al. (1992) The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.

external link
34.

Chan HS et al. (1991) P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma.

external link
35.

Safa AR et al. (1990) Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.

external link
36.

Taylor HR et al. (1990) Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection.

external link
37.

Kartner N et al. () Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies.

external link
38.

Fojo AT et al. (1987) Expression of a multidrug-resistance gene in human tumors and tissues.

external link
39.

Ruiz JC et al. (1989) Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.

external link
40.

Riordan JR et al. () Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines.

external link
41.

Chen CJ et al. (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

external link
42.

Bell DR et al. (1987) Chromosomal location of human P-glycoprotein gene sequences.

external link
43.

Trent JM et al. (1987) Clarification of the chromosomal assignment of the human P-glycoprotein/mdr1 gene: possible coincidence with the cystic fibrosis and c-met oncogene.

external link
44.

Slovak ML et al. (1987) Cytogenetic alterations associated with the acquisition of doxorubicin resistance: possible significance of chromosome 7 alterations.

external link
45.

Callen DF et al. (1987) Localization of the human multiple drug resistance gene, MDR1, to 7q21.1.

external link
46.

Ueda K et al. (1987) Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

external link
47.

Roninson IB et al. (1986) Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

external link
48.

Shen DW et al. (1986) Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.

external link
49.

Croop JM et al. (1988) Genetics of multidrug resistance.

external link
50.

Ueda K et al. (1987) The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

external link
51.

Gros P et al. () Isolation and expression of a complementary DNA that confers multidrug resistance.

external link
52.

Fojo A et al. (1986) Localization of multidrug resistance-associated DNA sequences to human chromosome 7.

external link
53.

Choi KH et al. (1988) An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.

external link
54.

Ueda K et al. (1987) Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

external link
55.

Martinsson T et al. (1987) Localization of the multidrug resistance-associated 170 kDa P-glycoprotein gene to mouse chromosome 5 and to homogeneously staining regions in multidrug-resistant mouse cells by in situ hybridization.

external link
56.

Ueda K et al. (1986) The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.

external link
57.

NCBI article

NCBI 5243 external link
58.

OMIM.ORG article

Omim 171050 external link
59.

Wikipedia Artikel

Wikipedia DE (Multidrug-Resistance-Protein_1) external link
Update: 14. August 2020
Copyright © 2005-2024 Zentrum für Nephrologie und Stoffwechsel, Dr. Mato Nagel
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Deutschland, Tel.: +49-3576-287922, Fax: +49-3576-287944
Seitenüberblick | Webmail | Haftungsausschluss | Datenschutz | Impressum