Multidrug-Resistenz-Protein 1
Das ABCB1-Gen kodiert ein Transportprotein, welches am Metabolismus verschiedener Medikamente beteiligt ist. Verschiedene Variationen werden im Zusammenhang mit einer inflammatorischen Darmerkrankung gesehen.
Gentests:
Forschung |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Siddiqui A et al. (2003) Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.
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2. |
Gros P et al. (1986) Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins.
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3. |
Baldini N et al. (1995) Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome.
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4. |
Schinkel AH et al. (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.
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5. |
van Helvoort A et al. (1996) MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.
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6. |
Mickley LA et al. (1997) Gene rearrangement: a novel mechanism for MDR-1 gene activation.
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7. |
Kim RB et al. (1998) The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
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8. |
Randolph GJ et al. (1998) A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels.
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9. |
Lankas GR et al. () Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice.
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10. |
Smit JW et al. (1999) Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure.
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11. |
Hoffmeyer S et al. (2000) Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.
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12. |
Synold TW et al. (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux.
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13. |
Schaeffeler E et al. (2001) Frequency of C3435T polymorphism of MDR1 gene in African people.
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14. |
Mealey KL et al. (2001) Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.
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15. |
Brant SR et al. (2003) MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.
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16. |
Tang K et al. (2004) Genomic evidence for recent positive selection at the human MDR1 gene locus.
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17. |
Neff MW et al. (2004) Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage.
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18. |
Zimprich F et al. (2004) Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy.
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19. |
Tan NC et al. (2004) Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy.
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20. |
Tate SK et al. (2005) Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin.
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21. |
Dong J et al. (2005) Structural basis of energy transduction in the transport cycle of MsbA.
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22. |
Wang YC et al. (2006) Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines.
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23. |
Dawson RJ et al. (2006) Structure of a bacterial multidrug ABC transporter.
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24. |
Kimchi-Sarfaty C et al. (2007) A "silent" polymorphism in the MDR1 gene changes substrate specificity.
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25. |
Sims-Mourtada J et al. (2007) Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport.
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26. |
Aller SG et al. (2009) Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
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27. |
Bao L et al. (2012) Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298.
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28. |
Katayama K et al. (2014) Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function.
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29. |
Pastan I et al. (1987) Multiple-drug resistance in human cancer.
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30. |
Panwala CM et al. (1998) A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis.
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31. |
Ho GT et al. (2006) ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach.
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32. |
de Lannoy IA et al. (1992) The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.
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33. |
Trezise AE et al. (1992) The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.
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34. |
Chan HS et al. (1991) P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma.
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35. |
Safa AR et al. (1990) Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.
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36. |
Taylor HR et al. (1990) Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection.
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37. |
Kartner N et al. () Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies.
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38. |
Fojo AT et al. (1987) Expression of a multidrug-resistance gene in human tumors and tissues.
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39. |
Ruiz JC et al. (1989) Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.
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40. |
Riordan JR et al. () Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines.
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41. |
Chen CJ et al. (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.
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42. |
Bell DR et al. (1987) Chromosomal location of human P-glycoprotein gene sequences.
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43. |
Trent JM et al. (1987) Clarification of the chromosomal assignment of the human P-glycoprotein/mdr1 gene: possible coincidence with the cystic fibrosis and c-met oncogene.
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44. |
Slovak ML et al. (1987) Cytogenetic alterations associated with the acquisition of doxorubicin resistance: possible significance of chromosome 7 alterations.
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45. |
Callen DF et al. (1987) Localization of the human multiple drug resistance gene, MDR1, to 7q21.1.
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46. |
Ueda K et al. (1987) Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.
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47. |
Roninson IB et al. (1986) Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.
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48. |
Shen DW et al. (1986) Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.
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49. |
Croop JM et al. (1988) Genetics of multidrug resistance.
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50. |
Ueda K et al. (1987) The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.
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51. |
Gros P et al. () Isolation and expression of a complementary DNA that confers multidrug resistance.
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52. |
Fojo A et al. (1986) Localization of multidrug resistance-associated DNA sequences to human chromosome 7.
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53. |
Choi KH et al. (1988) An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.
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54. |
Ueda K et al. (1987) Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.
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55. |
Martinsson T et al. (1987) Localization of the multidrug resistance-associated 170 kDa P-glycoprotein gene to mouse chromosome 5 and to homogeneously staining regions in multidrug-resistant mouse cells by in situ hybridization.
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56. |
Ueda K et al. (1986) The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.
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57. |
NCBI article
NCBI 5243
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58. |
OMIM.ORG article
Omim 171050
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59. |
Wikipedia Artikel
Wikipedia DE (Multidrug-Resistance-Protein_1)
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Update: 14. August 2020