Amyloid beta (A4) Vorläuferprotein
Das APP-Gen kodiert ein Membranprotein dessen Spaltprodukte verschiedene biologischen Funktionen dienen. Wenn diese Spaltprodukte nicht vollständig beseitigt werden können und akkumulieren kann eine Alzheimer-Erkrankung oder eine and zerebroarterielle Amyloidose entstehen.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Glenner GG et al. (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.
|
2. |
Ni Y et al. (2006) Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.
|
3. |
Levy E et al. (1990) Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.
|
4. |
Grabowski TJ et al. (2001) Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy.
|
5. |
Greenberg SM et al. (2003) Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation.
|
6. |
Obici L et al. (2005) A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.
|
7. |
Rovelet-Lecrux A et al. (2006) APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.
|
8. |
Revesz T et al. (2009) Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies.
|
9. |
Bugiani O et al. (2010) Hereditary cerebral hemorrhage with amyloidosis associated with the E693K mutation of APP.
|
10. |
Heneka MT et al. (2013) NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
|
11. |
DeMattos RB et al. (2004) ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.
|
12. |
Dodart JC et al. (2005) Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.
|
13. |
Ancolio K et al. (1999) Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease.
|
14. |
Gervais FG et al. (1999) Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.
|
15. |
Schenk D et al. (1999) Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
|
16. |
Campion D et al. (1999) Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum.
|
17. |
Vassar R et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
|
18. |
Yan R et al. (1999) Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
|
19. |
Bales KR et al. (1999) Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease.
|
20. |
Sennvik K et al. (2000) Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients.
|
21. |
Lorenzo A et al. (2000) Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.
|
22. |
Miravalle L et al. (2000) Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.
|
23. |
Murrell JR et al. (2000) Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene.
|
24. |
Kumar-Singh S et al. (2000) Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.
|
25. |
Kang DE et al. (2000) Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.
|
26. |
Janus C et al. () A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.
|
27. |
Morgan D et al. () A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.
|
28. |
Kamal A et al. (2000) Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I.
|
29. |
Takahashi M et al. (2000) Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.
|
30. |
Kojro E et al. (2001) Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.
|
31. |
Walsh DM et al. (2001) In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease.
|
32. |
Wyss-Coray T et al. (2001) TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.
|
33. |
Jankowsky JL et al. (2001) Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.
|
34. |
Iwata N et al. (2001) Metabolic regulation of brain Abeta by neprilysin.
|
35. |
Roberds SL et al. (2001) BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
|
36. |
Cherny RA et al. (2001) Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
|
37. |
Cao X et al. (2001) A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.
|
38. |
De Jonghe C et al. (2001) Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.
|
39. |
Lewis J et al. (2001) Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
|
40. |
Götz J et al. (2001) Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils.
|
41. |
Nilsberth C et al. (2001) The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.
|
42. |
Puglielli L et al. (2001) Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.
|
43. |
Weggen S et al. (2001) A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.
|
44. |
Petersen RC et al. (2001) Current concepts in mild cognitive impairment.
|
45. |
Kamal A et al. (2001) Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP.
|
46. |
Greenfield JP et al. (2002) Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis.
|
47. |
DeMattos RB et al. (2002) Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.
|
48. |
Dineley KT et al. (2002) Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins.
|
49. |
Bucciantini M et al. (2002) Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases.
|
50. |
Walsh DM et al. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.
|
51. |
Dodart JC et al. (2002) Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.
|
52. |
Sugarman MC et al. (2002) Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.
|
53. |
Taru H et al. (2002) Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism.
|
54. |
Pasalar P et al. (2002) An Iranian family with Alzheimer's disease caused by a novel APP mutation (Thr714Ala).
|
55. |
Francis R et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
|
56. |
Lashuel HA et al. (2002) Neurodegenerative disease: amyloid pores from pathogenic mutations.
|
57. |
Simons A et al. (2002) Evidence for a copper-binding superfamily of the amyloid precursor protein.
|
58. |
Wilson CA et al. (2002) Presenilins are not required for A beta 42 production in the early secretory pathway.
|
59. |
Baek SH et al. (2002) Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.
|
60. |
Pfeifer M et al. (2002) Cerebral hemorrhage after passive anti-Abeta immunotherapy.
|
61. |
Farris W et al. (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
|
62. |
Takasugi N et al. (2003) The role of presenilin cofactors in the gamma-secretase complex.
|
63. |
Kamenetz F et al. (2003) APP processing and synaptic function.
|
64. |
Morelli L et al. (2003) Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme.
|
65. |
Kayed R et al. (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis.
|
66. |
Phiel CJ et al. (2003) GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.
|
67. |
Hol EM et al. (2003) Frameshifted beta-amyloid precursor protein (APP+1) is a secretory protein, and the level of APP+1 in cerebrospinal fluid is linked to Alzheimer pathology.
|
68. |
Mullan M et al. (1992) A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
|
69. |
Hendriks L et al. (1992) Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.
|
70. |
Mant R et al. (1992) Schizophrenia scepticism.
|
71. |
Carter DA et al. (1992) More missense in amyloid gene.
|
72. |
Jones CT et al. (1992) Mutation in codon 713 of the beta amyloid precursor protein gene presenting with schizophrenia.
|
73. |
Kamino K et al. (1992) Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region.
|
74. |
Lehman EJ et al. (2003) Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse.
|
75. |
Netzer WJ et al. (2003) Gleevec inhibits beta-amyloid production but not Notch cleavage.
|
76. |
Zhou Y et al. (2003) Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.
|
77. |
Citron M et al. (1992) Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
|
78. |
Leissring MA et al. (2003) Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.
|
79. |
Ohno M et al. (2004) BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.
|
80. |
Muresan Z et al. (2004) A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment.
|
81. |
Iijima K et al. (2004) Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease.
|
82. |
Lustbader JW et al. (2004) ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.
|
83. |
Reddy PH et al. (2004) Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease.
|
84. |
Postina R et al. (2004) A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model.
|
85. |
Karlinsky H et al. (1992) Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the beta-amyloid precursor protein gene.
|
86. |
Krezowski J et al. (2004) Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression.
|
87. |
Rossi G et al. (2004) A family with Alzheimer disease and strokes associated with A713T mutation of the APP gene.
|
88. |
Lleó A et al. (2004) Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.
|
89. |
Hutter-Paier B et al. (2004) The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.
|
90. |
Cheng IH et al. (2004) Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.
|
91. |
Lee EB et al. (2005) BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo.
|
92. |
Petkova AT et al. (2005) Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils.
|
93. |
Edwards-Lee T et al. (2005) An African American family with early-onset Alzheimer disease and an APP (T714I) mutation.
|
94. |
Lazarov O et al. (2005) Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.
|
95. |
Saito T et al. (2005) Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.
|
96. |
Pardossi-Piquard R et al. (2005) Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.
|
97. |
Raux G et al. (2005) Molecular diagnosis of autosomal dominant early onset Alzheimer's disease: an update.
|
98. |
McGowan E et al. (2005) Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.
|
99. |
Grimm MO et al. (2005) Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin.
|
100. |
Balbín M et al. (1992) A novel mutation in the beta-protein coding region of the amyloid beta-protein precursor (APP) gene.
|
101. |
Yue X et al. (2005) Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model.
|
102. |
Tanzi RE et al. (1992) Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.
|
103. |
Guo JP et al. (2006) Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease.
|
104. |
Cai D et al. (2006) Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.
|
105. |
Tagawa K et al. (1991) Alzheimer's disease amyloid beta-clipping enzyme (APP secretase): identification, purification, and characterization of the enzyme.
|
106. |
Godbolt AK et al. (2006) A second family with familial AD and the V717L APP mutation has a later age at onset.
|
107. |
Lesné S et al. (2006) A specific amyloid-beta protein assembly in the brain impairs memory.
|
108. |
Pastorino L et al. (2006) The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.
|
109. |
Galvan V et al. (2006) Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.
|
110. |
Theuns J et al. (2006) Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.
|
111. |
Choi DS et al. (2006) PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.
|
112. |
Goate A et al. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
|
113. |
van Duijn CM et al. (1991) Amyloid precursor protein gene mutation in early-onset Alzheimer's disease.
|
114. |
Naruse S et al. (1991) Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
|
115. |
Schellenberg GD et al. (1991) APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease.
|
116. |
Bakker E et al. (1991) DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type)
|
117. |
Colton CA et al. (2006) NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease.
|
118. |
Mueller-Steiner S et al. (2006) Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
|
119. |
Meyer-Luehmann M et al. (2006) Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.
|
120. |
Adler MJ et al. (1991) Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts.
|
121. |
Tesseur I et al. (2006) Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology.
|
122. |
Chen AC et al. (2007) Response to: Pardossi-Piquard et al., "Presenilin-Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP." Neuron 46, 541-554.
|
123. |
Pardossi-Piquard R et al. (2007) Response to correspondence: Pardossi-Piquard et al., "Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betAAPP and APLP." Neuron 46, 541-554.
|
124. |
Guyant-Maréchal L et al. (2007) Variations in the APP gene promoter region and risk of Alzheimer disease.
|
125. |
Munter LM et al. (2007) GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.
|
126. |
El Khoury J et al. (2007) Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.
|
127. |
Kanekiyo T et al. (2007) Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid.
|
128. |
Liu Q et al. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.
|
129. |
Khan AA et al. (2007) Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo.
|
130. |
Meyer-Luehmann M et al. (2008) Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.
|
131. |
Basun H et al. (2008) Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease.
|
132. |
Town T et al. (2008) Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
|
133. |
Faghihi MA et al. (2008) Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase.
|
134. |
Brody DL et al. (2008) Amyloid-beta dynamics correlate with neurological status in the injured human brain.
|
135. |
Du H et al. (2008) Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
|
136. |
Schilling S et al. (2008) Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.
|
137. |
Guyant-Marechal I et al. (2008) Intrafamilial diversity of phenotype associated with app duplication.
|
138. |
Yoshioka K et al. (1991) The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.
|
139. |
Nikolaev A et al. (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.
|
140. |
Laurén J et al. (2009) Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.
|
141. |
Murrell J et al. (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.
|
142. |
Di Fede G et al. (2009) A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.
|
143. |
Loane DJ et al. (2009) Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury.
|
144. |
Fombonne J et al. (2009) Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction.
|
145. |
Hassan WM et al. (2009) AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model.
|
146. |
Chartier-Harlin MC et al. (1991) Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.
|
147. |
Burns MP et al. (2009) Parkin promotes intracellular Abeta1-42 clearance.
|
148. |
Tong Y et al. (2010) COL25A1 triggers and promotes Alzheimer's disease-like pathology in vivo.
|
149. |
Mitchell JC et al. (2009) X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
|
150. |
Kang JE et al. (2009) Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.
|
151. |
Iijima-Ando K et al. (2010) A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.
|
152. |
Munter LM et al. (2010) Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.
|
153. |
Iijima K et al. (2010) Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.
|
154. |
Duce JA et al. (2010) Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.
|
155. |
Eisele YS et al. (2010) Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.
|
156. |
Yoshikai S et al. (1990) Genomic organization of the human amyloid beta-protein precursor gene.
|
157. |
Cissé M et al. (2011) Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.
|
158. |
Esch FS et al. (1990) Cleavage of amyloid beta peptide during constitutive processing of its precursor.
|
159. |
Smith RP et al. (1990) Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein.
|
160. |
Chu J et al. (2011) 5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
|
161. |
Stieren ES et al. (2011) Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein.
|
162. |
Barrett PJ et al. (2012) The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.
|
163. |
Nussbaum JM et al. (2012) Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.
|
164. |
Jonsson T et al. (2012) A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.
|
165. |
Ahn HJ et al. (2014) A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice.
|
166. |
Van Nostrand WE et al. (1989) Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor.
|
167. |
Korenberg JR et al. (1989) The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05.
|
168. |
Oesch B et al. (1985) A cellular gene encodes scrapie PrP 27-30 protein.
|
169. |
Robakis NK et al. (1987) Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome.
|
170. |
Kang J et al. () The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
|
171. |
St George-Hyslop PH et al. (1987) Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease.
|
172. |
Tanzi RE et al. (1987) The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease.
|
173. |
Ponte P et al. (1988) A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.
|
174. |
Tanzi RE et al. (1988) Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.
|
175. |
Kitaguchi N et al. (1988) Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity.
|
176. |
Tanzi RE et al. (1987) Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.
|
177. |
Delabar JM et al. (1987) Beta amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome.
|
178. |
Podlisny MB et al. (1987) Gene dosage of the amyloid beta precursor protein in Alzheimer's disease.
|
179. |
Warren AC et al. (1987) beta-Amyloid gene is not present in three copies in autopsy-validated Alzheimer's disease.
|
180. |
Patterson D et al. (1988) Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21.
|
181. |
Robakis NK et al. (1987) Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.
|
182. |
Masters CL et al. (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome.
|
183. |
Murdoch GH et al. (1988) Beta-amyloid gene dosage in Alzheimer's disease.
|
184. |
Jenkins EC et al. (1988) Fine mapping of an Alzheimer disease-associated gene encoding beta-amyloid protein.
|
185. |
Selkoe DJ et al. (1987) Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.
|
186. |
Lovett M et al. (1987) The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16.
|
187. |
Goldgaber D et al. (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.
|
188. |
Haass C et al. (1995) The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
|
189. |
Kounnas MZ et al. (1995) LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation.
|
190. |
Kaneko I et al. (1995) Suppression of mitochondrial succinate dehydrogenase, a primary target of beta-amyloid, and its derivative racemized at Ser residue.
|
191. |
Zeldenrust SR et al. (1993) RFLP analysis for APP 717 mutations associated with Alzheimer's disease.
|
192. |
LaFerla FM et al. (1995) The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice.
|
193. |
Games D et al. (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.
|
194. |
Citron M et al. (1994) Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.
|
195. |
Felsenstein KM et al. (1994) Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation.
|
196. |
Coon H et al. (1993) C to T nucleotide substitution in codon 713 of amyloid precursor protein gene not found in 86 unrelated schizophrenics from multiplex families.
|
197. |
Peacock ML et al. (1994) Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease.
|
198. |
Suzuki N et al. (1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.
|
199. |
Schmaier AH et al. (1993) Protease nexin-2/amyloid beta protein precursor. A tight-binding inhibitor of coagulation factor IXa.
|
200. |
Sandbrink R et al. (1994) Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons.
|
201. |
St George-Hyslop P et al. (1994) Alzheimer's disease and possible gene interaction.
|
202. |
Jarrett JT et al. (1993) The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.
|
203. |
Carter D et al. (1993) No mutation in codon 713 of the amyloid precursor gene in schizophrenic patients.
|
204. |
Multhaup G et al. (1996) The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)
|
205. |
Yamatsuji T et al. (1996) G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.
|
206. |
Tang MX et al. (1996) Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease.
|
207. |
Yan SD et al. (1996) RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease.
|
208. |
Hsiao K et al. (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice.
|
209. |
Duff K et al. (1996) Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.
|
210. |
Maruyama K et al. (1996) Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).
|
211. |
Citron M et al. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
|
212. |
Tienari PJ et al. (1997) Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons.
|
213. |
Eckman CB et al. (1997) A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
|
214. |
Wyss-Coray T et al. (1997) Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease.
|
215. |
Narita M et al. (1997) Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.
|
216. |
Sturchler-Pierrat C et al. (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.
|
217. |
van Leeuwen FW et al. (1998) Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients.
|
218. |
De Strooper B et al. (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
|
219. |
Xu H et al. (1998) Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
|
220. |
Simons M et al. (1998) Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.
|
221. |
Di Luca M et al. (1998) Differential level of platelet amyloid beta precursor protein isoforms: an early marker for Alzheimer disease.
|
222. |
Cras P et al. (1998) Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation.
|
223. |
Sisodia SS et al. (1998) A role for the beta-amyloid precursor protein in memory?
|
224. |
Meziane H et al. (1998) Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.
|
225. |
Calhoun ME et al. (1998) Neuron loss in APP transgenic mice.
|
226. |
De Jonghe C et al. (1998) Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion.
|
227. |
Orphanet article
Orphanet ID 121393
|
228. |
NCBI article
NCBI 351
|
229. |
OMIM.ORG article
Omim 104760
|
230. |
Wikipedia Artikel
Wikipedia DE (Amyloid-Precursor-Protein)
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Update: 14. August 2020