Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Amyloid beta (A4) Vorläuferprotein

Das APP-Gen kodiert ein Membranprotein dessen Spaltprodukte verschiedene biologischen Funktionen dienen. Wenn diese Spaltprodukte nicht vollständig beseitigt werden können und akkumulieren kann eine Alzheimer-Erkrankung oder eine and zerebroarterielle Amyloidose entstehen.

Gentests:

Klinisch Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Multiplex ligationsabhängige Amplifikation
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Alzheimer Erkrankung
APOE
APP
CLU
CYP2D6
HFE
Zerebroarterielle Amyloidose vom Holländischen Typ
APP

Referenzen:

1.

Glenner GG et al. (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.

external link
2.

Ni Y et al. (2006) Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.

external link
3.

Levy E et al. (1990) Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

external link
4.

Grabowski TJ et al. (2001) Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy.

external link
5.

Greenberg SM et al. (2003) Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation.

external link
6.

Obici L et al. (2005) A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.

external link
7.

Rovelet-Lecrux A et al. (2006) APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.

external link
8.

Revesz T et al. (2009) Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies.

external link
9.

Bugiani O et al. (2010) Hereditary cerebral hemorrhage with amyloidosis associated with the E693K mutation of APP.

external link
10.

Heneka MT et al. (2013) NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.

external link
11.

DeMattos RB et al. (2004) ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

external link
12.

Dodart JC et al. (2005) Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.

external link
13.

Ancolio K et al. (1999) Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease.

external link
14.

Gervais FG et al. (1999) Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.

external link
15.

Schenk D et al. (1999) Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.

external link
16.

Campion D et al. (1999) Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum.

external link
17.

Vassar R et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

external link
18.

Yan R et al. (1999) Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.

external link
19.

Bales KR et al. (1999) Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease.

external link
20.

Sennvik K et al. (2000) Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients.

external link
21.

Lorenzo A et al. (2000) Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

external link
22.

Miravalle L et al. (2000) Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.

external link
23.

Murrell JR et al. (2000) Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene.

external link
24.

Kumar-Singh S et al. (2000) Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.

external link
25.

Kang DE et al. (2000) Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

external link
26.

Janus C et al. () A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

external link
27.

Morgan D et al. () A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

external link
28.

Kamal A et al. (2000) Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I.

external link
29.

Takahashi M et al. (2000) Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.

external link
30.

Kojro E et al. (2001) Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

external link
31.

Walsh DM et al. (2001) In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease.

external link
32.

Wyss-Coray T et al. (2001) TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

external link
33.

Jankowsky JL et al. (2001) Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.

external link
34.

Iwata N et al. (2001) Metabolic regulation of brain Abeta by neprilysin.

external link
35.

Roberds SL et al. (2001) BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.

external link
36.

Cherny RA et al. (2001) Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

external link
37.

Cao X et al. (2001) A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.

external link
38.

De Jonghe C et al. (2001) Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

external link
39.

Lewis J et al. (2001) Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

external link
40.

Götz J et al. (2001) Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils.

external link
41.

Nilsberth C et al. (2001) The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.

external link
42.

Puglielli L et al. (2001) Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.

external link
43.

Weggen S et al. (2001) A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.

external link
44.

Petersen RC et al. (2001) Current concepts in mild cognitive impairment.

external link
45.

Kamal A et al. (2001) Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP.

external link
46.

Greenfield JP et al. (2002) Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis.

external link
47.

DeMattos RB et al. (2002) Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.

external link
48.

Dineley KT et al. (2002) Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins.

external link
49.

Bucciantini M et al. (2002) Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases.

external link
50.

Walsh DM et al. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.

external link
51.

Dodart JC et al. (2002) Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

external link
52.

Sugarman MC et al. (2002) Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.

external link
53.

Taru H et al. (2002) Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism.

external link
54.

Pasalar P et al. (2002) An Iranian family with Alzheimer's disease caused by a novel APP mutation (Thr714Ala).

external link
55.

Francis R et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.

external link
56.

Lashuel HA et al. (2002) Neurodegenerative disease: amyloid pores from pathogenic mutations.

external link
57.

Simons A et al. (2002) Evidence for a copper-binding superfamily of the amyloid precursor protein.

external link
58.

Wilson CA et al. (2002) Presenilins are not required for A beta 42 production in the early secretory pathway.

external link
59.

Baek SH et al. (2002) Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.

external link
60.

Pfeifer M et al. (2002) Cerebral hemorrhage after passive anti-Abeta immunotherapy.

external link
61.

Farris W et al. (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.

external link
62.

Takasugi N et al. (2003) The role of presenilin cofactors in the gamma-secretase complex.

external link
63.

Kamenetz F et al. (2003) APP processing and synaptic function.

external link
64.

Morelli L et al. (2003) Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme.

external link
65.

Kayed R et al. (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis.

external link
66.

Phiel CJ et al. (2003) GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

external link
67.

Hol EM et al. (2003) Frameshifted beta-amyloid precursor protein (APP+1) is a secretory protein, and the level of APP+1 in cerebrospinal fluid is linked to Alzheimer pathology.

external link
68.

Mullan M et al. (1992) A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.

external link
69.

Hendriks L et al. (1992) Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

external link
70.

Mant R et al. (1992) Schizophrenia scepticism.

external link
71.

Carter DA et al. (1992) More missense in amyloid gene.

external link
72.

Jones CT et al. (1992) Mutation in codon 713 of the beta amyloid precursor protein gene presenting with schizophrenia.

external link
73.

Kamino K et al. (1992) Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region.

external link
74.

Lehman EJ et al. (2003) Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse.

external link
75.

Netzer WJ et al. (2003) Gleevec inhibits beta-amyloid production but not Notch cleavage.

external link
76.

Zhou Y et al. (2003) Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.

external link
77.

Citron M et al. (1992) Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.

external link
78.

Leissring MA et al. (2003) Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

external link
79.

Ohno M et al. (2004) BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.

external link
80.

Muresan Z et al. (2004) A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment.

external link
81.

Iijima K et al. (2004) Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease.

external link
82.

Lustbader JW et al. (2004) ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

external link
83.

Reddy PH et al. (2004) Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease.

external link
84.

Postina R et al. (2004) A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model.

external link
85.

Karlinsky H et al. (1992) Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the beta-amyloid precursor protein gene.

external link
86.

Krezowski J et al. (2004) Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression.

external link
87.

Rossi G et al. (2004) A family with Alzheimer disease and strokes associated with A713T mutation of the APP gene.

external link
88.

Lleó A et al. (2004) Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.

external link
89.

Hutter-Paier B et al. (2004) The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

external link
90.

Cheng IH et al. (2004) Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.

external link
91.

Lee EB et al. (2005) BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo.

external link
92.

Petkova AT et al. (2005) Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils.

external link
93.

Edwards-Lee T et al. (2005) An African American family with early-onset Alzheimer disease and an APP (T714I) mutation.

external link
94.

Lazarov O et al. (2005) Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.

external link
95.

Saito T et al. (2005) Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

external link
96.

Pardossi-Piquard R et al. (2005) Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.

external link
97.

Raux G et al. (2005) Molecular diagnosis of autosomal dominant early onset Alzheimer's disease: an update.

external link
98.

McGowan E et al. (2005) Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.

external link
99.

Grimm MO et al. (2005) Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin.

external link
100.

Balbín M et al. (1992) A novel mutation in the beta-protein coding region of the amyloid beta-protein precursor (APP) gene.

external link
101.

Yue X et al. (2005) Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model.

external link
102.

Tanzi RE et al. (1992) Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.

external link
103.

Guo JP et al. (2006) Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease.

external link
104.

Cai D et al. (2006) Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.

external link
105.

Tagawa K et al. (1991) Alzheimer's disease amyloid beta-clipping enzyme (APP secretase): identification, purification, and characterization of the enzyme.

external link
106.

Godbolt AK et al. (2006) A second family with familial AD and the V717L APP mutation has a later age at onset.

external link
107.

Lesné S et al. (2006) A specific amyloid-beta protein assembly in the brain impairs memory.

external link
108.

Pastorino L et al. (2006) The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.

external link
109.

Galvan V et al. (2006) Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

external link
110.

Theuns J et al. (2006) Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.

external link
111.

Choi DS et al. (2006) PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.

external link
112.

Goate A et al. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

external link
113.

van Duijn CM et al. (1991) Amyloid precursor protein gene mutation in early-onset Alzheimer's disease.

external link
114.

Naruse S et al. (1991) Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.

external link
115.

Schellenberg GD et al. (1991) APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease.

external link
116.

Bakker E et al. (1991) DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type)

external link
117.

Colton CA et al. (2006) NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease.

external link
118.

Mueller-Steiner S et al. (2006) Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.

external link
119.

Meyer-Luehmann M et al. (2006) Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.

external link
120.

Adler MJ et al. (1991) Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts.

external link
121.

Tesseur I et al. (2006) Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology.

external link
122.

Chen AC et al. (2007) Response to: Pardossi-Piquard et al., "Presenilin-Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP." Neuron 46, 541-554.

external link
123.

Pardossi-Piquard R et al. (2007) Response to correspondence: Pardossi-Piquard et al., "Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betAAPP and APLP." Neuron 46, 541-554.

external link
124.

Guyant-Maréchal L et al. (2007) Variations in the APP gene promoter region and risk of Alzheimer disease.

external link
125.

Munter LM et al. (2007) GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

external link
126.

El Khoury J et al. (2007) Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

external link
127.

Kanekiyo T et al. (2007) Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid.

external link
128.

Liu Q et al. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.

external link
129.

Khan AA et al. (2007) Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo.

external link
130.

Meyer-Luehmann M et al. (2008) Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.

external link
131.

Basun H et al. (2008) Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease.

external link
132.

Town T et al. (2008) Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.

external link
133.

Faghihi MA et al. (2008) Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase.

external link
134.

Brody DL et al. (2008) Amyloid-beta dynamics correlate with neurological status in the injured human brain.

external link
135.

Du H et al. (2008) Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.

external link
136.

Schilling S et al. (2008) Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.

external link
137.

Guyant-Marechal I et al. (2008) Intrafamilial diversity of phenotype associated with app duplication.

external link
138.

Yoshioka K et al. (1991) The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.

external link
139.

Nikolaev A et al. (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.

external link
140.

Laurén J et al. (2009) Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.

external link
141.

Murrell J et al. (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.

external link
142.

Di Fede G et al. (2009) A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.

external link
143.

Loane DJ et al. (2009) Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury.

external link
144.

Fombonne J et al. (2009) Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction.

external link
145.

Hassan WM et al. (2009) AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model.

external link
146.

Chartier-Harlin MC et al. (1991) Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.

external link
147.

Burns MP et al. (2009) Parkin promotes intracellular Abeta1-42 clearance.

external link
148.

Tong Y et al. (2010) COL25A1 triggers and promotes Alzheimer's disease-like pathology in vivo.

external link
149.

Mitchell JC et al. (2009) X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.

external link
150.

Kang JE et al. (2009) Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.

external link
151.

Iijima-Ando K et al. (2010) A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.

external link
152.

Munter LM et al. (2010) Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.

external link
153.

Iijima K et al. (2010) Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.

external link
154.

Duce JA et al. (2010) Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.

external link
155.

Eisele YS et al. (2010) Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.

external link
156.

Yoshikai S et al. (1990) Genomic organization of the human amyloid beta-protein precursor gene.

external link
157.

Cissé M et al. (2011) Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.

external link
158.

Esch FS et al. (1990) Cleavage of amyloid beta peptide during constitutive processing of its precursor.

external link
159.

Smith RP et al. (1990) Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein.

external link
160.

Chu J et al. (2011) 5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.

external link
161.

Stieren ES et al. (2011) Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein.

external link
162.

Barrett PJ et al. (2012) The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.

external link
163.

Nussbaum JM et al. (2012) Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.

external link
164.

Jonsson T et al. (2012) A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.

external link
165.

Ahn HJ et al. (2014) A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice.

external link
166.

Van Nostrand WE et al. (1989) Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor.

external link
167.

Korenberg JR et al. (1989) The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05.

external link
168.

Oesch B et al. (1985) A cellular gene encodes scrapie PrP 27-30 protein.

external link
169.

Robakis NK et al. (1987) Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome.

external link
170.

Kang J et al. () The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.

external link
171.

St George-Hyslop PH et al. (1987) Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease.

external link
172.

Tanzi RE et al. (1987) The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease.

external link
173.

Ponte P et al. (1988) A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.

external link
174.

Tanzi RE et al. (1988) Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.

external link
175.

Kitaguchi N et al. (1988) Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity.

external link
176.

Tanzi RE et al. (1987) Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

external link
177.

Delabar JM et al. (1987) Beta amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome.

external link
178.

Podlisny MB et al. (1987) Gene dosage of the amyloid beta precursor protein in Alzheimer's disease.

external link
179.

Warren AC et al. (1987) beta-Amyloid gene is not present in three copies in autopsy-validated Alzheimer's disease.

external link
180.

Patterson D et al. (1988) Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21.

external link
181.

Robakis NK et al. (1987) Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

external link
182.

Masters CL et al. (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome.

external link
183.

Murdoch GH et al. (1988) Beta-amyloid gene dosage in Alzheimer's disease.

external link
184.

Jenkins EC et al. (1988) Fine mapping of an Alzheimer disease-associated gene encoding beta-amyloid protein.

external link
185.

Selkoe DJ et al. (1987) Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.

external link
186.

Lovett M et al. (1987) The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16.

external link
187.

Goldgaber D et al. (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.

external link
188.

Haass C et al. (1995) The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.

external link
189.

Kounnas MZ et al. (1995) LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation.

external link
190.

Kaneko I et al. (1995) Suppression of mitochondrial succinate dehydrogenase, a primary target of beta-amyloid, and its derivative racemized at Ser residue.

external link
191.

Zeldenrust SR et al. (1993) RFLP analysis for APP 717 mutations associated with Alzheimer's disease.

external link
192.

LaFerla FM et al. (1995) The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice.

external link
193.

Games D et al. (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.

external link
194.

Citron M et al. (1994) Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.

external link
195.

Felsenstein KM et al. (1994) Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation.

external link
196.

Coon H et al. (1993) C to T nucleotide substitution in codon 713 of amyloid precursor protein gene not found in 86 unrelated schizophrenics from multiplex families.

external link
197.

Peacock ML et al. (1994) Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease.

external link
198.

Suzuki N et al. (1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

external link
199.

Schmaier AH et al. (1993) Protease nexin-2/amyloid beta protein precursor. A tight-binding inhibitor of coagulation factor IXa.

external link
200.

Sandbrink R et al. (1994) Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons.

external link
201.

St George-Hyslop P et al. (1994) Alzheimer's disease and possible gene interaction.

external link
202.

Jarrett JT et al. (1993) The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.

external link
203.

Carter D et al. (1993) No mutation in codon 713 of the amyloid precursor gene in schizophrenic patients.

external link
204.

Multhaup G et al. (1996) The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)

external link
205.

Yamatsuji T et al. (1996) G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

external link
206.

Tang MX et al. (1996) Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease.

external link
207.

Yan SD et al. (1996) RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease.

external link
208.

Hsiao K et al. (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice.

external link
209.

Duff K et al. (1996) Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.

external link
210.

Maruyama K et al. (1996) Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).

external link
211.

Citron M et al. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.

external link
212.

Tienari PJ et al. (1997) Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons.

external link
213.

Eckman CB et al. (1997) A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).

external link
214.

Wyss-Coray T et al. (1997) Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease.

external link
215.

Narita M et al. (1997) Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.

external link
216.

Sturchler-Pierrat C et al. (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.

external link
217.

van Leeuwen FW et al. (1998) Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients.

external link
218.

De Strooper B et al. (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.

external link
219.

Xu H et al. (1998) Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.

external link
220.

Simons M et al. (1998) Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.

external link
221.

Di Luca M et al. (1998) Differential level of platelet amyloid beta precursor protein isoforms: an early marker for Alzheimer disease.

external link
222.

Cras P et al. (1998) Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation.

external link
223.

Sisodia SS et al. (1998) A role for the beta-amyloid precursor protein in memory?

external link
224.

Meziane H et al. (1998) Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

external link
225.

Calhoun ME et al. (1998) Neuron loss in APP transgenic mice.

external link
226.

De Jonghe C et al. (1998) Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion.

external link
227.

Orphanet article

Orphanet ID 121393 external link
228.

NCBI article

NCBI 351 external link
229.

OMIM.ORG article

Omim 104760 external link
230.

Wikipedia Artikel

Wikipedia DE (Amyloid-Precursor-Protein) external link
Update: 14. August 2020
Copyright © 2005-2020 Zentrum für Nephrologie und Stoffwechsel, Dr. Mato Nagel
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Deutschland, Tel.: +49-3576-287922, Fax: +49-3576-287944
Seitenüberblick | Webmail | Haftungsausschluss | Datenschutz