Glypican 5
Das GPC5-Gen kodiert eine membranständige Komponente von Heparansulfat-Proteoglycanen. Es wird angenommen, dass diese Proteine eine Rolle bei Zelleilung und Wachstum spielen. Eine Assoziation verscheidener Polymorphismen mit nephrotischem Syndrom wurde gefunden.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Neat MJ et al. (2001) Localisation of a novel region of recurrent amplification in follicular lymphoma to an approximately 6.8 Mb region of 13q32-33.
|
2. |
Mao X et al. (2002) Comparative genomic hybridization analysis of primary cutaneous B-cell lymphomas: identification of common genomic alterations in disease pathogenesis.
|
3. |
Yu W et al. (2003) GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines.
|
4. |
Okamoto K et al. (2011) Common variation in GPC5 is associated with acquired nephrotic syndrome.
|
5. |
Veugelers M et al. (1997) Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family.
|
6. |
Knuutila S et al. (1998) DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies.
|
7. |
NCBI article
NCBI 2262
|
8. |
OMIM.ORG article
Omim 602446
|
Update: 14. August 2020