Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Clusterin

Das CLU-Gen kodiert ein sezerniertes Chaperon (Hilfsproteine bei der Faltung anderer Proteine), welches unter Stressbedingungen auch im Zytosol gefunden wird. Genetische Variationen dieses Gens wurden mit verschiedenen Erkrankungen wie Alzheimer, atypisches hämolytisch urämisces Syndrom und FSGS assoziert.

Gentests:

Klinisch Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Alzheimer Erkrankung
APOE
APP
CLU
CYP2D6
HFE
Hämolytisch Urämisches Syndrom
ADAMTS13
C3
C4BPA
C4BPB
CD46
CFB
CFH
CFHR1
CFHR2
CFHR3
CFHR4
CFHR5
CFI
CLU
DGKE
Methylmalonazidurie
Methylmalonazidurie Typ mut
MUT
Methylmalonazidurie mit Homozysteinurie cblC
MMACHC
Methylmalonazidurie mit Homozysteinurie cblD
MMADHC
PIGA
PLG
THBD
Fokal segmentale Glomerulosklerose (FSGS)
ALG13
ARHGAP24
CLU
Hereditäre FSGS vom Typ 1
ACTN4
Hereditäre FSGS vom Typ 2
TRPC6
Hereditäre FSGS vom Typ 3
CD2AP
Hereditäre FSGS vom Typ 4
APOL1
Hereditäre FSGS vom Typ 5
INF2
Hereditäre FSGS vom Typ 6
MYO1E
Hereditäre FSGS vom Typ 7
PAX2
ITGA9
LAMA5
NXF5
Apolipoprotein-Mangel
APOA5
APOB
APOC1
APOC2
APOC3
APOE
APOL1
APOM
Apolipoprotein A1-Mangel
APOA1
Apolipoprotein A2-Mangel
APOA2
Apolipoprotein F-Mangel
APOF
Apolipoprotein H-Mangel
APOH
CLU

Referenzen:

1.

McLaughlin L et al. (2000) Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis.

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2.

Navab M et al. (1997) Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.

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3.

Bertrand P et al. (1995) Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.

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4.

Birkenmeier EH et al. (1993) Sulfated glycoprotein-2 (Sgp-2) maps to mouse chromosome 14.

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5.

Danik M et al. (1993) Localization of sulfated glycoprotein-2/clusterin mRNA in the rat brain by in situ hybridization.

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6.

Fink TM et al. (1993) Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) gene.

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7.

Wong P et al. (1994) Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration.

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8.

Wong P et al. (1993) Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis.

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9.

Dragunow M et al. (1995) Clusterin accumulates in dying neurons following status epilepticus.

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10.

Duguid JR et al. (1989) Changes in brain gene expression shared by scrapie and Alzheimer disease.

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11.

Kirszbaum L et al. (1989) Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: a link between the complement and reproductive systems.

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12.

Murphy BF et al. (1988) SP-40,40, a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis.

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13.

de Silva HV et al. (1990) Purification and characterization of apolipoprotein J.

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14.

Slawin K et al. (1990) Chromosomal assignment of the human homologue encoding SGP-2.

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15.

O'Bryan MK et al. (1990) Human seminal clusterin (SP-40,40). Isolation and characterization.

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16.

Purrello M et al. (1991) The gene for SP-40,40, human homolog of rat sulfated glycoprotein 2, rat clusterin, and rat testosterone-repressed prostate message 2, maps to chromosome 8.

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17.

de Silva HV et al. (1990) Apolipoprotein J: structure and tissue distribution.

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18.

Ståhl AL et al. (2009) A novel mutation in the complement regulator clusterin in recurrent hemolytic uremic syndrome.

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19.

Kamboh MI et al. (1991) Genetic studies of human apolipoproteins. XX. Genetic polymorphism of apolipoprotein J and its impact on quantitative lipid traits in normolipidemic subjects.

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20.

Zenkel M et al. (2006) Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material.

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21.

Tobe T et al. (1991) Assignment of a human serum glycoprotein SP-40,40 gene (CLI) to chromosome 8.

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22.

Zhang H et al. (2005) Clusterin inhibits apoptosis by interacting with activated Bax.

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23.

Jenne DE et al. (1992) Clusterin: the intriguing guises of a widely expressed glycoprotein.

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24.

Ostermeier GC et al. (2004) Reproductive biology: delivering spermatozoan RNA to the oocyte.

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25.

Dietzsch E et al. (1992) Regional localization of the gene for clusterin (SP-40,40; gene symbol CLI) to human chromosome 8p12-->p21.

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26.

Chen X et al. (2003) Clusterin as a biomarker in murine and human intestinal neoplasia.

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27.

Ghiggeri GM et al. (2002) Depletion of clusterin in renal diseases causing nephrotic syndrome.

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28.

Han BH et al. (2001) Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia.

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29.

DeMattos RB et al. (2004) ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

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30.

NCBI article

NCBI 1191 external link
31.

OMIM.ORG article

Omim 185430 external link
Update: 14. August 2020
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