Histamine N-Methyltransferase
Das Gen kodiert eines von zwei wichtigen Enzymen beim Histaminabbau. Eine Variation in diesem Gen ist in Assoziation mit Asthma bronchiale beschrieben worden. Weiterhin wird ein zusammenhang mit Histamin-Intoleranz vermutet.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Sasaki Y et al. (2000) Lack of association between atopic asthma and polymorphisms of the histamine H1 receptor, histamine H2 receptor, and histamine N-methyltransferase genes.
|
2. |
Yan L et al. (2000) Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma.
|
3. |
Barnes WG et al. (2004) Characterization of a new mRNA species from the human histamine N-methyltransferase gene.
|
4. |
Sharma S et al. (2005) Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population.
|
5. |
Yamauchi K et al. (1994) Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway.
|
6. |
Price RA et al. (1993) Genetic segregation analysis of red blood cell (RBC) histamine N-methyltransferase (HNMT) activity.
|
7. |
Aksoy S et al. (1996) Human histamine N-methyltransferase gene: structural characterization and chromosomal location.
|
8. |
Preuss CV et al. (1998) Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity.
|
9. |
OMIM.ORG article
Omim 605238
|
10. |
Orphanet article
Orphanet ID 448453
|
11. |
NCBI article
NCBI 3176
|
Update: 14. August 2020