Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

AIDS-Pogression

Die Progression der AIDS-Erkrankung scheint von Varianten im INFG-Gen abzuhängen.

Gliederung

HIV-Resistenz
AIDS-Pogression
IFNG
CCR5
CXCR1
HIV 1-Infektionsanfälligkeit
HIV-1-Virämieanfälligkeit

Referenzen:

1.

Mandl JN et al. (2008) Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections.

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2.

Schindler M et al. (2006) Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.

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3.

Cressey TR et al. (2007) Pharmacogenetics of antiretroviral drugs for the treatment of HIV-infected patients: an update.

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4.

Jennes W et al. (2006) Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands.

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5.

Wilkin TJ et al. (2007) HIV type 1 chemokine coreceptor use among antiretroviral-experienced patients screened for a clinical trial of a CCR5 inhibitor: AIDS Clinical Trial Group A5211.

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6.

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8.

Triboulet R et al. (2007) Suppression of microRNA-silencing pathway by HIV-1 during virus replication.

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9.

Gulick RM et al. (2007) Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211.

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10.

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11.

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12.

Huang J et al. (2007) Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes.

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13.

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14.

Burt TD et al. (2008) Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.

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15.

He W et al. (2008) Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility.

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16.

Granelli-Piperno A et al. (2006) HIV-1 selectively infects a subset of nonmaturing BDCA1-positive dendritic cells in human blood.

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17.

Kulkarni H et al. (2009) The Duffy-null state is associated with a survival advantage in leukopenic HIV-infected persons of African ancestry.

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18.

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19.

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20.

Cagliani R et al. (2010) Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection.

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21.

Sironi M et al. (2012) A common polymorphism in TLR3 confers natural resistance to HIV-1 infection.

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22.

Zhang W et al. (2011) T-cell differentiation factor CBF-β regulates HIV-1 Vif-mediated evasion of host restriction.

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23.

Jäger S et al. (2011) Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.

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24.

Richardson MW et al. (2012) Kruppel-like factor 2 modulates CCR5 expression and susceptibility to HIV-1 infection.

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25.

Harman AN et al. (2015) HIV Blocks Interferon Induction in Human Dendritic Cells and Macrophages by Dysregulation of TBK1.

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26.

Yoh SM et al. (2015) PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.

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27.

Sperandio S et al. (2015) TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability.

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28.

Usami Y et al. (2015) SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef.

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29.

Rosa A et al. (2015) HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.

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30.

Ramsuran V et al. (2018) Elevated expression impairs HIV control through inhibition of NKG2A-expressing cells.

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31.

Faure S et al. (2000) Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1.

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32.

Shin HD et. al. (2000) Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10.

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33.

Carrington M et al. (1999) HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.

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34.

Thomas R et al. (2009) HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.

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35.

Vasilescu A et al. (2007) A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients.

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36.

An P et al. (2003) A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals.

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37.

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38.

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39.

Liu R et al. (1996) Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.

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40.

Dean M et al. (1996) Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study.

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41.

Smith MW et al. (1997) Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study.

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42.

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43.

Martin MP et al. (1998) Genetic acceleration of AIDS progression by a promoter variant of CCR5.

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44.

Liu H et al. (1999) Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression.

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45.

Migueles SA et al. (2000) HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors.

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46.

Rosenwasser LJ et. al. (1997) Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10).

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47.

Gao X et al. (2001) Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS.

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48.

An P et al. (2002) Modulating influence on HIV/AIDS by interacting RANTES gene variants.

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49.

Martin MP et al. (2002) Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS.

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50.

Modi WS et al. (2003) MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission.

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51.

O'Brien SJ et al. (2004) Human genes that limit AIDS.

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52.

Nolan D et al. (2004) Impact of host genetics on HIV disease progression and treatment: new conflicts on an ancient battleground.

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53.

None (2004) HIV-host interactions: vital to the virus and key to its inhibition.

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54.

Lassen K et al. (2004) The multifactorial nature of HIV-1 latency.

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55.

Martin MP et al. (2004) Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection.

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56.

Kaslow RA et al. (2005) Influence of host genetic variation on susceptibility to HIV type 1 infection.

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57.

Gonzalez E et al. (2005) The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility.

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58.

Colobran R et al. (2005) Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients.

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59.

Soriano A et al. (2005) Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS.

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60.

Gao X et al. (2005) AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis.

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Update: 14. August 2020
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