Suszeptibilität für systemischen Lupus erythematodes

Wu H et al. (2007) Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus.

Yang Y et al. (2007) Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans.

Boteva L et al. (2012) Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

Barreto M et al. (2004) Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus.

Lee YH et al. (2005) CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis.

Napirei M et al. (2000) Features of systemic lupus erythematosus in Dnase1-deficient mice.

Yasutomo K et al. (2001) Mutation of DNASE1 in people with systemic lupus erythematosus.

Shin HD et al. (2004) Common DNase I polymorphism associated with autoantibody production among systemic lupus erythematosus patients.

Balada E et al. (2008) Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus.

Sanghera DK et al. (1997) Identification of structural mutations in the fifth domain of apolipoprotein H (beta 2-glycoprotein I) which affect phospholipid binding.

Linker-Israeli M et al. (1999) Association of IL-6 gene alleles with systemic lupus erythematosus (SLE) and with elevated IL-6 expression.

Lee YH et al. (2006) Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility.

Hom G et al. (2008) Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

Kyogoku C et al. (2004) Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.

Orrú V et al. (2009) A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.

Kyogoku C et al. (2002) Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility.

Su K et al. (2004) A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus.

McGaha TL et al. (2005) Restoration of tolerance in lupus by targeted inhibitory receptor expression.

Blank MC et al. (2005) Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus.

Floto RA et al. (2005) Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts.

Willcocks LC et al. (2010) A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.

Mueller M et al. (2013) Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.

Lee-Kirsch MA et al. (2007) Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

Yocum MW et al. () Monozygotic twins discordant for systemic lupus erythematosus.

Beaucher WN et al. (1977) Familial lupus erythematosus. Antibodies to DNA in household dogs.

Horn JR et al. () Mixed connective tissue disease in siblings.

Miller KB et al. (1979) Familial abnormalities of suppressor-cell function in systemic lupus erythematosus.

None (1979) Systemic lupus erythematosus, autoimmunity, sex and inheritance.

Serdula MK et al. (1979) Frequency of systemic lupus erythematosus in different ethnic groups in Hawaii.

Brustein D et al. (1977) Familial lupus erythematosus.

Knight JG et al. (1978) Three genes for lupus nephritis in NZB x NZW mice.

Arnett FC et al. (1976) Studies in familial systemic lupus erythematosus.

DeHoratius RJ et al. (1975) Anti-nucleic acid antibodies in systemic lupus erythematosus patients and their families. Incidence and correlation with lymphocytotoxic antibodies.

Block SR et al. (1975) Studies of twins with systemic lupus erythematosus. A review of the literature and presentation of 12 additional sets.

Sturfelt G et al. (1990) Homozygous C4A deficiency in systemic lupus erythematosus: analysis of patients from a defined population.

Stohl W et al. (1985) Systemic lupus erythematosus with deficiency of the T4 epitope on T helper/inducer cells.

Sakane T et al. (1989) Familial occurrence of impaired interleukin-2 activity and increased peripheral blood B cells actively secreting immunoglobulins in systemic lupus erythematosus.

Wong DW et al. (1988) Nonlinkage of the T cell receptor alpha, beta, and gamma genes to systemic lupus erythematosus in multiplex families.

Levcovitz H et al. (1988) Segregation of lymphocyte low-molecular-weight DNA and antinuclear-antibodies in a family with systemic lupus erythematosus in first cousins.

Green JR et al. (1986) The association of HLA-linked genes with systemic lupus erythematosus.

Mackie IJ et al. (1987) Familial lupus anticoagulants.

Baer AN et al. (1986) Further evidence for the lack of association between acetylator phenotype and systemic lupus erythematosus.

Fronek Z et al. (1986) Systemic lupus erythematosus is not genetically linked to the beta chain of the T cell receptor.

Halpern R et al. (1985) Familial systemic lupus erythematosus. Presence of a cross-reactive idiotype in healthy family members.

Theofilopoulos AN et al. (1985) Murine models of systemic lupus erythematosus.

None (1971) Lupus erythematosus panniculitis (profundus).

None (1972) Family studies in systemic lupus erythematosus. I. A proband material from central eastern Norway.

Siegel M et al. (1965) A comparative family study of rheumatoid arthritis and systemic lupus erythematosus.

Lappat EJ et al. (1968) A familial study of procainamide-induced systemic lupus erythematosus. A question of pharmacogenetic polymorphism.

None (1974) Systemic lupus erythematosus in the community. Incidence, prevalence, outcome, and first symptoms; the high prevalence in black women.

Reed WB et al. (1972) Hereditary inflammatory vasculitis with persistent nodules. A genetically-determined new entity probably related to lupus erythematosus.

Kohler PF et al. (1974) Hereditary angioedema and "familial" lupus erythematosus in identical twin boys.

None (1973) Familial systemic lupus erythematosus.

None (1972) Illness resembling lupus erythematosus in mothers of boys with chronic granulomatous disease.

Larsen RA et al. (1972) Family studies in systemic lupus erythematosus (SLE). IX. Thyroid diseases and antibodies.

Siegel M et al. () Epidemiologic studies on systemic lupus erythematosus. Comparative data for New York City and Jefferson County, Alabama, 1956-1965.

Batchelor JR et al. (1980) Hydralazine-induced systemic lupus erythematosus: influence of HLA-DR and sex on susceptibility.

Solomon G et al. (1983) Use of monoclonal antibodies to identify shared idiotypes on human antibodies to native DNA from patients with systemic lupus erythematosus.

Steinberg AD et al. (1984) NIH conference. Systemic lupus erythematosus: insights from animal models.

Hughes GR et al. (1983) Genetics of systemic lupus erythematosus.

Fielder AH et al. (1983) Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.

Diamond B et al. (1984) Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.

Reveille JD et al. (1983) Familial systemic lupus erythematosus: immunogenetic studies in eight families.

Lahita RG et al. (1983) Familial systemic lupus erythematosus in males.

Tan EM et al. (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus.

Reidenberg MM et al. (1980) Acetylator phenotype in idiopathic systemic lupus erythematosus.

Exner T et al. (1980) Familial association of the lupus anticoagulant.

Weinberg JB et al. (1980) Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis.

Morel L et al. (1994) Polygenic control of susceptibility to murine systemic lupus erythematosus.

Sibley JT et al. (1993) Familial systemic lupus erythematosus characterized by digital ischemia.

None (1996) Systemic lupus erythematosus.

Vyse TJ et al. (1996) Genetic analysis of autoimmune disease.

None (1995) Genetics of systemic lupus erythematosus.

Wu J et al. (1996) Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.

Vyse TJ et al. (1996) Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice.

García CO et al. (1996) Autoantibody profile in African-American patients with lupus nephritis.

Lessard E et al. (1997) Role of CYP2D6 in the N-hydroxylation of procainamide.

Elçioglu N et al. (1998) Maternal systemic lupus erythematosus and chondrodysplasia punctata in two sibs: phenocopy or coincidence?

Austin-Ward E et al. (1998) Neonatal lupus syndrome: a case with chondrodysplasia punctata and other unusual manifestations.

None (1998) Chondrodysplasia punctata and maternal systemic lupus erythematosus.

Gaffney PM et al. (1998) A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families.

Shai R et al. (1999) Genome-wide screen for systemic lupus erythematosus susceptibility genes in multiplex families.

Kelly TE et al. (1999) Chondrodysplasia punctata stemming from maternal lupus erythematosus.

Mohan C et al. (1999) Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies.

Lessard E et al. (1999) Involvement of CYP2D6 activity in the N-oxidation of procainamide in man.

Lindqvist AK et al. (2000) A susceptibility locus for human systemic lupus erythematosus (hSLE1) on chromosome 2q.

Gaffney PM et al. (2000) Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families.

Gross JA et al. (2000) TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease.

Gray-McGuire C et al. (2000) Genome scan of human systemic lupus erythematosus by regression modeling: evidence of linkage and epistasis at 4p16-15.2.

Zhang J et al. (2001) Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus.

Solomou EE et al. (2001) Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus.

DeGiorgio LA et al. (2001) A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus.

Blanco P et al. (2001) Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.

Stein CM et al. (2002) Increased prevalence of renal disease in systemic lupus erythematosus families with affected male relatives.

Leadbetter EA et al. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors.

Graham RR et al. (2002) Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus.

Quintero-Del-Rio AI et al. (2002) The genetics of systemic lupus erythematosus stratified by renal disease: linkage at 10q22.3 (SLEN1), 2q34-35 (SLEN2), and 11p15.6 (SLEN3).

Kelly JA et al. (2002) The genetics of systemic lupus erythematosus: putting the pieces together.

Johanneson B et al. (2002) A major susceptibility locus for systemic lupus erythemathosus maps to chromosome 1q31.

Scofield RH et al. (2003) Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13.

Prokunina L et al. (2002) A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans.

Sun Y et al. (2002) Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease.

Molokhia M et al. (2003) Relation of risk of systemic lupus erythematosus to west African admixture in a Caribbean population.

Baechler EC et al. (2003) Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus.

Nakamura K et al. (2003) Genetic dissection of anxiety in autoimmune disease.

None (1964) ANTINUCLEAR ANTIBODIES IN FAMILIES OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.

Kamat SS et al. (2003) Triplets with systemic lupus erythematosus.

Russell AI et al. (2004) Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus.

Li N et al. (2004) Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.

Xu L et al. (2004) Human lupus T cells resist inactivation and escape death by upregulating COX-2.

Tournoy J et al. (2004) Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.

Kozlowski K et al. (2004) Chondrodysplasia punctata in siblings and maternal lupus erythematosus.

Sigurdsson S et al. (2005) Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

Tao D et al. (2005) CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus.

Barber DF et al. (2005) PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus.

Xing C et al. (2005) Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members.

Lee YH et al. (2005) Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis.

Huerta PT et al. (2006) Immunity and behavior: antibodies alter emotion.

Aitman TJ et al. (2006) Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans.

Graham RR et al. (2006) A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.

Kowal C et al. (2006) Human lupus autoantibodies against NMDA receptors mediate cognitive impairment.

Fanciulli M et al. (2007) FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.

Remmers EF et al. (2007) STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

Kamatani Y et al. (2008) Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population.

Cunninghame Graham DS et al. (2008) Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.

et al. (2008) Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.

Kozyrev SV et al. (2008) Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus.

Nath SK et al. (2008) A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.

Oishi T et al. (2008) A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population.

Willcocks LC et al. (2008) Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.

Graham RR et al. (2008) Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

Musone SL et al. (2008) Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.

Sthoeger ZM et al. (2009) High alpha-defensin levels in patients with systemic lupus erythematosus.

Sánchez E et al. (2009) Identification of a new putative functional IL18 gene variant through an association study in systemic lupus erythematosus.

Han JW et al. (2009) Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.

Gateva V et al. (2009) A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.

Myouzen K et al. (2010) Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus.

Niederer HA et al. (2010) Copy number, linkage disequilibrium and disease association in the FCGR locus.

Guiducci C et al. (2010) TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.

Olsson LM et al. (2012) Copy number variation of the gene NCF1 is associated with rheumatoid arthritis.

Manjarrez-Orduño N et al. (2012) CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.

Kshirsagar S et al. (2014) Akt-dependent enhanced migratory capacity of Th17 cells from children with lupus nephritis.

Talaei N et al. (2015) Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.

Zhao J et al. (2017) A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.

Bialas AR et al. (2017) Microglia-dependent synapse loss in type I interferon-mediated lupus.

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