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Suszeptibilität für systemischen Lupus erythematodes

Bei genetischen Variationen an verschiedenen Loci wurde eine Assoziation mit systemischem Lupus erythematodes.

Gliederung

Autoimmunerkrankungen
Anfälligkeit für systemischen Lupus erythematodes 9
Autoimmune Polyendokrinopathie
Membranöse Glomerulonephritis
Neigung zu Vitiligo-assoziierter multipler Autoimmunerkrankung 1
Neigung zu autoimmunbedingten Schilddrüsenerkrankungen
Suszeptibilität für Typ 1 Diabetes 01
Suszeptibilität für Zöliakie
Suszeptibilität für systemischen Lupus erythematodes
Anfälligkeit für systemischen Lupus erythematodes 9
CR2
CTLA4
DNASE1
FCGR2A
FCGR2B
PTPN22
Suszeptibilität für Lupus-Nephritis
FCGR2A
TREX1

Referenzen:

1.

Wu H et al. (2007) Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus.

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2.

Yang Y et al. (2007) Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans.

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3.

Boteva L et al. (2012) Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

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4.

Barreto M et al. (2004) Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus.

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5.

Lee YH et al. (2005) CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis.

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6.

Napirei M et al. (2000) Features of systemic lupus erythematosus in Dnase1-deficient mice.

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7.

Yasutomo K et al. (2001) Mutation of DNASE1 in people with systemic lupus erythematosus.

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8.

Shin HD et al. (2004) Common DNase I polymorphism associated with autoantibody production among systemic lupus erythematosus patients.

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9.

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10.

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11.

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13.

Hom G et al. (2008) Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

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14.

Kyogoku C et al. (2004) Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.

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15.

Orrú V et al. (2009) A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.

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16.

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17.

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19.

Blank MC et al. (2005) Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus.

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20.

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21.

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22.

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23.

Lee-Kirsch MA et al. (2007) Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

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24.

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37.

Sakane T et al. (1989) Familial occurrence of impaired interleukin-2 activity and increased peripheral blood B cells actively secreting immunoglobulins in systemic lupus erythematosus.

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38.

Wong DW et al. (1988) Nonlinkage of the T cell receptor alpha, beta, and gamma genes to systemic lupus erythematosus in multiplex families.

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39.

Levcovitz H et al. (1988) Segregation of lymphocyte low-molecular-weight DNA and antinuclear-antibodies in a family with systemic lupus erythematosus in first cousins.

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40.

Green JR et al. (1986) The association of HLA-linked genes with systemic lupus erythematosus.

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41.

Mackie IJ et al. (1987) Familial lupus anticoagulants.

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42.

Baer AN et al. (1986) Further evidence for the lack of association between acetylator phenotype and systemic lupus erythematosus.

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43.

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44.

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45.

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46.

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47.

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Lappat EJ et al. (1968) A familial study of procainamide-induced systemic lupus erythematosus. A question of pharmacogenetic polymorphism.

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51.

Reed WB et al. (1972) Hereditary inflammatory vasculitis with persistent nodules. A genetically-determined new entity probably related to lupus erythematosus.

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52.

Kohler PF et al. (1974) Hereditary angioedema and "familial" lupus erythematosus in identical twin boys.

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53.

None (1973) Familial systemic lupus erythematosus.

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54.

None (1972) Illness resembling lupus erythematosus in mothers of boys with chronic granulomatous disease.

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55.

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56.

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57.

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58.

Solomon G et al. (1983) Use of monoclonal antibodies to identify shared idiotypes on human antibodies to native DNA from patients with systemic lupus erythematosus.

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59.

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60.

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61.

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62.

Diamond B et al. (1984) Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.

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63.

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64.

Lahita RG et al. (1983) Familial systemic lupus erythematosus in males.

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65.

Tan EM et al. (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus.

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66.

Reidenberg MM et al. (1980) Acetylator phenotype in idiopathic systemic lupus erythematosus.

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67.

Exner T et al. (1980) Familial association of the lupus anticoagulant.

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68.

Weinberg JB et al. (1980) Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis.

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69.

Morel L et al. (1994) Polygenic control of susceptibility to murine systemic lupus erythematosus.

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70.

Sibley JT et al. (1993) Familial systemic lupus erythematosus characterized by digital ischemia.

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71.

None (1996) Systemic lupus erythematosus.

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72.

Vyse TJ et al. (1996) Genetic analysis of autoimmune disease.

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73.

None (1995) Genetics of systemic lupus erythematosus.

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74.

Wu J et al. (1996) Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.

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75.

Vyse TJ et al. (1996) Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice.

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76.

García CO et al. (1996) Autoantibody profile in African-American patients with lupus nephritis.

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77.

Lessard E et al. (1997) Role of CYP2D6 in the N-hydroxylation of procainamide.

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78.

Elçioglu N et al. (1998) Maternal systemic lupus erythematosus and chondrodysplasia punctata in two sibs: phenocopy or coincidence?

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79.

Austin-Ward E et al. (1998) Neonatal lupus syndrome: a case with chondrodysplasia punctata and other unusual manifestations.

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80.

None (1998) Chondrodysplasia punctata and maternal systemic lupus erythematosus.

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81.

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82.

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83.

Kelly TE et al. (1999) Chondrodysplasia punctata stemming from maternal lupus erythematosus.

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84.

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85.

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86.

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87.

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88.

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89.

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90.

Zhang J et al. (2001) Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus.

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91.

Solomou EE et al. (2001) Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus.

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92.

DeGiorgio LA et al. (2001) A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus.

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93.

Blanco P et al. (2001) Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.

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94.

Stein CM et al. (2002) Increased prevalence of renal disease in systemic lupus erythematosus families with affected male relatives.

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95.

Leadbetter EA et al. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors.

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96.

Graham RR et al. (2002) Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus.

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97.

Quintero-Del-Rio AI et al. (2002) The genetics of systemic lupus erythematosus stratified by renal disease: linkage at 10q22.3 (SLEN1), 2q34-35 (SLEN2), and 11p15.6 (SLEN3).

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98.

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99.

Johanneson B et al. (2002) A major susceptibility locus for systemic lupus erythemathosus maps to chromosome 1q31.

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100.

Scofield RH et al. (2003) Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13.

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101.

Prokunina L et al. (2002) A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans.

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102.

Sun Y et al. (2002) Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease.

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103.

Molokhia M et al. (2003) Relation of risk of systemic lupus erythematosus to west African admixture in a Caribbean population.

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104.

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105.

Nakamura K et al. (2003) Genetic dissection of anxiety in autoimmune disease.

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106.

None (1964) ANTINUCLEAR ANTIBODIES IN FAMILIES OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.

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107.

Kamat SS et al. (2003) Triplets with systemic lupus erythematosus.

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108.

Russell AI et al. (2004) Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus.

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109.

Li N et al. (2004) Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.

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110.

Xu L et al. (2004) Human lupus T cells resist inactivation and escape death by upregulating COX-2.

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111.

Tournoy J et al. (2004) Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.

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112.

Kozlowski K et al. (2004) Chondrodysplasia punctata in siblings and maternal lupus erythematosus.

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113.

Sigurdsson S et al. (2005) Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

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114.

Tao D et al. (2005) CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus.

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115.

Barber DF et al. (2005) PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus.

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116.

Xing C et al. (2005) Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members.

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117.

Lee YH et al. (2005) Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis.

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118.

Huerta PT et al. (2006) Immunity and behavior: antibodies alter emotion.

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119.

Aitman TJ et al. (2006) Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans.

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120.

Graham RR et al. (2006) A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.

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121.

Kowal C et al. (2006) Human lupus autoantibodies against NMDA receptors mediate cognitive impairment.

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122.

Fanciulli M et al. (2007) FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.

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123.

Remmers EF et al. (2007) STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

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124.

Kamatani Y et al. (2008) Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population.

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125.

Cunninghame Graham DS et al. (2008) Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.

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126.

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127.

Kozyrev SV et al. (2008) Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus.

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128.

Nath SK et al. (2008) A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.

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129.

Oishi T et al. (2008) A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population.

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130.

Willcocks LC et al. (2008) Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.

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131.

Graham RR et al. (2008) Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

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132.

Musone SL et al. (2008) Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.

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133.

Sthoeger ZM et al. (2009) High alpha-defensin levels in patients with systemic lupus erythematosus.

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134.

Sánchez E et al. (2009) Identification of a new putative functional IL18 gene variant through an association study in systemic lupus erythematosus.

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135.

Han JW et al. (2009) Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.

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136.

Gateva V et al. (2009) A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.

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137.

Myouzen K et al. (2010) Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus.

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138.

Niederer HA et al. (2010) Copy number, linkage disequilibrium and disease association in the FCGR locus.

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139.

Guiducci C et al. (2010) TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.

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140.

Olsson LM et al. (2012) Copy number variation of the gene NCF1 is associated with rheumatoid arthritis.

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141.

Manjarrez-Orduño N et al. (2012) CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.

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142.

Kshirsagar S et al. (2014) Akt-dependent enhanced migratory capacity of Th17 cells from children with lupus nephritis.

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143.

Talaei N et al. (2015) Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.

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144.

Zhao J et al. (2017) A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.

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145.

Bialas AR et al. (2017) Microglia-dependent synapse loss in type I interferon-mediated lupus.

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Wikipedia Artikel

Wikipedia DE (Lupus_erythematodes) external link
Update: 14. August 2020
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