Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Systemische idiopathische juvenile Arthritis ist eine polygene Erkrankung, bei welcher die Gene LACC1, IL6, und MIF beteiligt sind. Bei der Erkrankung kommt es neben der juvenilen Arthritis zu extra-articulären Manifestationen wie Fieber und Hauteruptionen.
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Donn R et. al. (2002) Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis.
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De Benedetti F et. al. (2003) Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis.
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Symmons DP et. al. (1996) Pediatric rheumatology in the United Kingdom: data from the British Pediatric Rheumatology Group National Diagnostic Register.
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Glass DN et. al. (1999) Juvenile rheumatoid arthritis as a complex genetic trait.
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Thorne JE et. al. (2007) Juvenile idiopathic arthritis-associated uveitis: incidence of ocular complications and visual acuity loss.
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