Neigung zu arteriovenösen Fehlbildungen im Gehirn
Die Neigung zu arteriovenösen Fehlbildungen im Gehirn wird durch autosomal dominante Keimbahnmutationen im IL6-Gen und durch somatische Mutationen im KRAS-Gen beeinflusst.
Gliederung
Referenzen:
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Pawlikowska L et. al. (2004) Polymorphisms in genes involved in inflammatory and angiogenic pathways and the risk of hemorrhagic presentation of brain arteriovenous malformations. [^] |
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Chen Y et. al. (2006) Interleukin-6 involvement in brain arteriovenous malformations. [^] |
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Snead OC et. al. (1979) Familial arteriovenous malformation. [^] |
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Yokoyama K et. al. (1991) Familial occurrence of arteriovenous malformation of the brain. [^] |
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Boyd MC et. al. (1985) Familial arteriovenous malformations. Report of four cases in one family. [^] |
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Aberfeld DC et. al. (1981) Familial arteriovenous malformation of the brain. [^] |
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Murphy PA et. al. (2008) Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice. [^] |
| 8. |
Chen Y et. al. (2009) Soluble endoglin modulates aberrant cerebral vascular remodeling. [^] |
| 9. |
Nikolaev SI et. al. (2018) Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain. [^] |
