Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel

Neigung zu Vitiligo-assoziierter multipler Autoimmunerkrankung 1

Die Neigung zu Vitiligo-assoziierter multipler Autoimmunerkrankung 1 kann durch genetische Varianten im NLRP1-Gen, welches ein Apoptose-Regulator kodiert, vermittelt werden.

Gliederung

Erbliche Hauterkrankungen
Autoinflammation mit Arthritis und Dyskeratose
Chronische atypische neutrophile Dermatose mit Lipodystrophie und erhöhter Temperatur
Epidermolysis bullosa
Familiäre Acne inversa 1
Interleukin 36-Rezeptor-Antagonist-Mangel
Interstitielle Lungenerkrankung mit nephrotischem Syndrom und Epidemiolysis bullosa
Keratosis linearis - Ichthyosis congenita - sklerosierendes Keratoderm
Neigung zu Vitiligo-assoziierter multipler Autoimmunerkrankung 1
NLRP1
Nephropathie mit prätibialer epidermolysis bullosa und Schwerhörigkeit
Periodisches Fieber mit Beginn im Kindesalter-Pannikulitis-Dermatose-Syndrom
Piebaldismus
Pityriasis rubra pilaris
Psoriasis 02
Psoriasis 14
Psoriasis 15
Pyoderma gangraenosum, Acne und Hidradenitis suppurativa (PASH)
Pyogene Arthritis - Pyoderma gangraenosum - Akne - Syndrom

Referenzen:

1.

Jin Y et. al. (2007) NALP1 in vitiligo-associated multiple autoimmune disease.

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2.

Bader PI et. al. (1975) Vitiligo and dysgammaglobulinemia. A case report and family study.

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3.

Majumder PP et. al. (1988) A genetical model for vitiligo.

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4.

Goudie RB et. al. (1980) Unstable mutations in vitiligo, organ-specific autoimmune diseases, and multiple endocrine adenoma/peptic-ulcer syndrome.

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5.

Nath SK et. al. (1994) Genetic epidemiology of vitiligo: multilocus recessivity cross-validated.

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6.

Majumder PP et. al. (1993) Pattern of familial aggregation of vitiligo.

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7.

Nath SK et. al. (2001) Evidence for a susceptibility gene, SLEV1, on chromosome 17p13 in families with vitiligo-related systemic lupus erythematosus.

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8.

None (1959) Vitiligo.

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9.

Spritz RA et. al. (2004) Novel vitiligo susceptibility loci on chromosomes 7 (AIS2) and 8 (AIS3), confirmation of SLEV1 on chromosome 17, and their roles in an autoimmune diathesis.

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10.

Johansson CM et. al. (2004) Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus.

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11.

Jin Y et. al. (2010) Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.

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12.

Quan C et. al. (2010) Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.

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13.

Jin Y et. al. (2010) Common variants in FOXP1 are associated with generalized vitiligo.

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Update: 8. Mai 2019